Novel metabolites of warfarin produced byBeauveria bassianaandStreptomyces rimosus: a novel application of hplc- nmr
| Autor: | T. Rashid, P. J. Sidebottom, P. S. Marshall, Andrew R. Knaggs, R. J. P. Cannell, I. M. Ismail |
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| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
Magnetic Resonance Spectroscopy Molecular Structure biology Streptomycetaceae Health Toxicology and Mutagenesis Metabolite Streptomyces rimosus Beauveria bassiana General Medicine Fungi imperfecti Toxicology biology.organism_classification Biochemistry Streptomyces chemistry.chemical_compound Biotransformation chemistry Mitosporic Fungi Warfarin Actinomycetales Chromatography High Pressure Liquid |
| Zdroj: | Xenobiotica. 27:147-157 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.1080/004982597240659 |
| Popis: | 1. Biotransformation of warfarin by the fungus Beauveria bassiana (ATCC 7159) yielded the first reported phase II warfarin metabolite, 3'4'-dihydroxywarfarin-3'-[4-methoxyglucoside], another previously unreported metabolite, 3',4'-dihydroxywarfarin and also 4'-hydroxywarfarin. 2. Biotransformation of warfarin by Streptomyces rimosus (NRRL 2234) yielded the previously unreported metabolites, 12-hydroxywarfarin, 4'-hydroxy-11-methoxywarfarin, and also 7-hydroxywarfarin and 4'-hydroxywarfarin, which have not been previously reported as biotransformation products from this organism. 3. Hplc-nmr has been used to identify biotransformation products of warfarin by S. rimosus directly from the microbial broth without prior isolation and purification. |
| Databáze: | OpenAIRE |
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