A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy
| Autor: | Xiu Wang, Xiangle Zeng, Yawen Zhang, Jianchun Li, Yu-shuai Wang, Hairong Wang, Ranran Fan, Wenjun Pei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Proton Magnetic Resonance Spectroscopy
Dasatinib Pharmaceutical Science 02 engineering and technology 01 natural sciences Metastasis Rats Sprague-Dawley chemistry.chemical_compound Drug Delivery Systems inhibiting metastasis Cell Movement International Journal of Nanomedicine Drug Discovery Hyaluronic acid Tissue Distribution Hyaluronic Acid Cytotoxicity Micelles Original Research Drug Carriers Mice Inbred BALB C Cell Death Chemistry General Medicine 021001 nanoscience & nanotechnology Endocytosis Tumor Burden Drug delivery Female 0210 nano-technology HA targeting medicine.drug polymer Static Electricity Biophysics Mice Nude Breast Neoplasms Bioengineering 010402 general chemistry Hemolysis Rosiglitazone Biomaterials Breast cancer In vivo Cell Line Tumor micelle medicine Animals Humans Particle Size Body Weight Organic Chemistry technology industry and agriculture medicine.disease In vitro 0104 chemical sciences Drug Liberation Cancer research Nanoparticles |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Hairong Wang, Yawen Zhang, Xiangle Zeng, Wenjun Pei, Ranran Fan, Yushuai Wang, Xiu Wang, Jianchun Li School of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaCorrespondence: Jianchun LiSchool of Pharmacy, Bengbu Medical College, Bengbu, 233030, People’s Republic of ChinaTel +86 552-3175066Email Lijc66577@sohu.comAim: The metastasis of breast cancer is an important cause of tumor recurrence. This study highlights that tyrosine kinase inhibitors dasatinib (DAS) and rosiglitazone (ROZ) inhibit tumor growth and reduce the occurrence of tumor cell metastasis. Due to the poor water solubility, short half-time in the body of DAS and ROZ, which increases the difficulty of tumor treatment, as well as the demand for nano-drug delivery systems for organ-specific therapies.Methods: Hyaluronic acid (HA) and DAS are bonded by a pH-sensitive ester bond to form an HA-DAS polymer. Then, ROZ was added as the core, D-A-tocopherol polydiethylene glycol isosuccinate (TPGS) and HA-DAS were used as carriers to form HA-DAS and TPGS mixed micelle system loaded with ROZ (THDR-NPs). The size and structure of THDR-NPs were characterized, the drug release, stability and biosafety of THDR-NPs were studied. In vitro, the cytotoxicity, targeting effect and tumor metastasis inhibition of THDR-NPs were evaluated in human breast cancer cell lines. In addition, the selective potency of designed THDR-NPs in depleting was further verified in vivo in the tumor-bearing nude mice model.Results: The designed THDR-NPs have a particle size of less than 100 nm, good stability, biological safety and sustained release, and showed strong therapeutic effects on breast cancer models in vitro and in vivo. Moreover, it has been proved that THDR-NPs have the ability to inhibit tumor metastasis.Conclusion: DAS and ROZ were designed into micelles, the efficacy of THDR-NPs was higher than that of free drugs. These results indicate that nanoparticles have a good application prospect in the treatment of tumor metastasis.Keywords: HA targeting, inhibiting metastasis, polymer, micelle |
| Databáze: | OpenAIRE |
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