The p75 neurotrophin receptor is widely expressed in conventional papillary thyroid carcinoma
| Autor: | Manuel Sobrinho-Simões, Vítor Trovisco, Paula Soares, Ben Davidson, Ana Rocha, Philip Lazarovici, Björn Risberg, J.F Magalhaes, Inês Vieira de Castro |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Genetic Markers
Proto-Oncogene Proteins B-raf endocrine system Pathology medicine.medical_specialty endocrine system diseases Thyroid Gland Tropomyosin receptor kinase A Receptor Nerve Growth Factor Pathology and Forensic Medicine Thyroid carcinoma Biomarkers Tumor medicine Humans Low-affinity nerve growth factor receptor Thyroid Neoplasms Receptor trkA Thyroid cancer Cellular localization biology Thyroid Anatomical pathology medicine.disease Immunohistochemistry Adenocarcinoma Papillary medicine.anatomical_structure nervous system biology.protein Cancer research Neurotrophin |
| Zdroj: | Human Pathology. 37:562-568 |
| ISSN: | 0046-8177 |
| DOI: | 10.1016/j.humpath.2005.12.016 |
| Popis: | Papillary thyroid carcinomas (PTCs) are associated with alterations in several proto-oncogenes related with nervous system development and function, such as TrkA and RET, which are commonly rearranged in these carcinomas. The other oncogenic event recently identified in PTC is the BRAF V600E mutation. Because the role of TrkA was not completely elucidated in thyroid cancer ethiopathogenesis, we decided to study the expression of active, phosphorylated TrkA and of its coreceptor p75 neurotrophin receptor (p75 NTR) in a series of 92 PTC (37 lesions of conventional PTC, 28 of follicular variant of PTC [FVPTC], and 27 of other variants of PTC) as well as in 21 samples of normal thyroid and nonneoplastic thyroid lesions used as a controls. We observed neoexpression of p75 NTR in PTC, particularly in conventional PTC and in other variants of PTC displaying a papillary growth pattern, rather than in FVPTC. No immunoexpression of p75 NTR was observed in normal thyroid nor in nonneoplastic thyroid lesions. The cellular localization of p75 NTR immunoexpression was also significantly associated with the growth pattern of PTC, being much more frequently detected in an apical localization in PTC with papillary architecture than in PTC with a follicular or solid growth pattern. This apical localization of p75 NTR was significantly associated with the presence of BRAF V600E. No significant differences were detected between normal thyroid, nonneoplastic lesions, and PTC (or any PTC variant) regarding expression/activation of TrkA, thus suggesting that by itself and in contrast to p75 NTR, TrkA is not altered during PTC development. |
| Databáze: | OpenAIRE |
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