Beneficial Effects of Phyllanthus amarus Against High Fructose Diet Induced Insulin Resistance and Hepatic Oxidative Stress in Male Wistar Rats
| Autor: | Sudhakara Gujjala, Saralakumari Desireddy, Srinivasulu Nukala, Mallaiah Putakala |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Leptin Male medicine.disease_cause Protein oxidation Applied Microbiology and Biotechnology Biochemistry Antioxidants Lipid peroxidation Impaired glucose tolerance chemistry.chemical_compound Hyperinsulinemia Homeostasis Insulin General Medicine Fasting Organ Size Lipids Liver Adiponectin Biotechnology medicine.medical_specialty Bioengineering Fructose Biology 03 medical and health sciences Insulin resistance Internal medicine medicine Animals Rats Wistar Molecular Biology 030102 biochemistry & molecular biology Dose-Response Relationship Drug Plant Extracts Body Weight Water medicine.disease Diet Rats Oxidative Stress Phyllanthus 030104 developmental biology Endocrinology chemistry Metabolic syndrome Insulin Resistance Dyslipidemia Oxidative stress |
| Zdroj: | Applied biochemistry and biotechnology. 183(3) |
| ISSN: | 1559-0291 |
| Popis: | Insulin resistance (IR) is a characteristic feature of obesity, type 2 diabetes mellitus, and cardiovascular diseases. Emerging evidence suggests that the high-fructose consumption is a potential and important factor responsible for the rising incidence of IR. The present study investigates the beneficial effects of aqueous extract of Phyllanthus amarus (PAAE) on IR and oxidative stress in high-fructose (HF) fed male Wistar rats. HF diet (66% of fructose) and PAAE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 60 days. Fructose-fed rats showed weight gain, hyperglycemia, hyperinsulinemia, impaired glucose tolerance, impaired insulin sensitivity, dyslipidemia, hyperleptinemia, and hypoadiponectinemia (P |
| Databáze: | OpenAIRE |
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