Coherent phasic excitation during hippocampal ripples
| Autor: | Richard Kempter, Anja L. Dorrn, Christian Leibold, Dietmar Schmitz, Álvaro Tejero-Cantero, Jochen Winterer, Nikolaus Maier, Prateep Beed, James F.A. Poulet, Genela Morris |
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| Rok vydání: | 2011 |
| Předmět: |
Gabaergic transmission
Male Postsynaptic Current Neuroscience(all) Action Potentials Hippocampal formation 4 4'-Diisothiocyanostilbene-2 2'-Disulfonic Acid Hippocampus Synaptic Transmission GABA Antagonists 03 medical and health sciences Mice 0302 clinical medicine Animals Equilibrium potential gamma-Aminobutyric Acid 030304 developmental biology Physics 0303 health sciences General Neuroscience Pyramidal Cells Excitatory Postsynaptic Potentials Neural Inhibition Brain Waves Mice Inbred C57BL Excitatory postsynaptic potential Neuroscience 030217 neurology & neurosurgery Excitation |
| Zdroj: | Neuron. 72(1) |
| ISSN: | 1097-4199 |
| Popis: | SummaryHigh-frequency hippocampal network oscillations, or “ripples,” are thought to be involved in episodic memory. According to current theories, memory traces are represented by assemblies of principal neurons that are activated during ripple-associated network states. Here we performed in vivo and in vitro experiments to investigate the synaptic mechanisms during ripples. We discovered postsynaptic currents that are phase-locked to ripples and coherent among even distant CA1 pyramidal neurons. These fast currents are consistent with excitatory postsynaptic currents (EPSCs) as they are observed at the equilibrium potential of Cl−, and they display kinetics characteristic of EPSCs. Furthermore, they survived after intracellular blockade of GABAergic transmission and are effective to regulate the timing of action potentials. In addition, our data show a progressive synchronization of phasic excitation and inhibition during the course of ripples. Together, our results demonstrate the presence of phasic excitation during ripples reflecting an exquisite temporal coordination of assemblies of active pyramidal cells. |
| Databáze: | OpenAIRE |
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