Reversal of multidrug resistance by bis(phenylalkyl)amines and structurally related compounds
| Autor: | Avner Ramu, Nili Ramu |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Cancer Research Aniline Compounds Tertiary amine Chemistry Stereochemistry Leukemia P388 Pharmacology toxicology Drug Resistance Toxicology Ring (chemistry) Multiple drug resistance Mice Structure-Activity Relationship Oncology Phenothiazines Chemical groups Tumor Cells Cultured Structure–activity relationship Animals Pharmacology (medical) Amine gas treating Drug Interactions Alkyl |
| Zdroj: | Cancer chemotherapy and pharmacology. 34(5) |
| ISSN: | 0344-5704 |
| Popis: | We have previously reported that multidrug (MDR)-reversal activity can be exerted by compounds in which two ring structures of certain types are connected by one alkyl bridge to a secondary or tertiary amine group. In the present investigation we studied the MDR-reversal activity of compounds in which the two ring structures were connected by separate alkyl bridges to the amine group. The structure-activity relationship of these compounds verified previous findings on the structural features that support MDR-reversal activity as well as the features that reduce such activity. In addition, the present study reveals additional chemical groups and ring structures that support MDR-reversal activity as well as those that reduce it. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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