Why do Most Primary Bladder Neoplasms First Appear Around the Ureteric Orifices?
| Autor: | V. J. McKELVEY, L. H. Stewart, J. D. Biggart, E. S. Gillespie, S. R. Johnston, Kim L. O'Neill, PG McKenna |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Bladder base Urology Urinary Bladder urologic and male genital diseases Thymidine Kinase Ureter Bladder Neoplasm medicine Humans Nucleotide salvage Carcinogen Aged Mucous Membrane Urinary bladder business.industry Mucous membrane Anatomy Middle Aged female genital diseases and pregnancy complications Isoenzymes medicine.anatomical_structure Urinary Bladder Neoplasms Thymidine kinase Female business |
| Zdroj: | British Journal of Urology. 71:34-37 |
| ISSN: | 1464-410X 0007-1331 |
| Popis: | The majority of primary bladder neoplasms are known to arise within the mucosa around the ureteric orifices and bladder base. This may be due to the mucosa in this area being more susceptible to carcinogens than other areas of the bladder. Deficiency in the nucleotide salvage pathway enzyme thymidine kinase (TK), and especially its TK1 isozyme, has been shown to predispose cell lines to increased mutagenesis. Total TK and TK1 activities were measured in mucosal samples taken adjacent to the ureteric orifices and dome in 32 normal bladders and both total TK and TK1 were shown to be significantly decreased in the mucosa adjacent to the ureteric orifices. This may explain why primary bladder neoplasms occur more commonly in this site. |
| Databáze: | OpenAIRE |
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