Mitochondria-Targeted Compounds to Assess and Improve Human Sperm Function
| Autor: | Sandra Amaral, João Ramalho-Santos, Sara Escada-Rebelo, Maria Inês Cristo |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Male
Infertility Physiology Clinical Biochemistry Reproductive age Biology Bioinformatics Biochemistry Male infertility Semen medicine Humans Molecular Biology General Environmental Science Male factor Cell Biology medicine.disease Spermatozoa Sperm Mitochondria Oxidative Stress General Earth and Planetary Sciences Female Increased ROS production Reactive Oxygen Species Function (biology) Mitochondria targeted |
| Zdroj: | Antioxidants & Redox Signaling. 37:451-480 |
| ISSN: | 1557-7716 1523-0864 |
| Popis: | SIGNIFICANCE Currently 10-15% of couples in reproductive age face infertility issues. More importantly, male factor contributes to 50% of these cases (either alone or in combination with female causes). Amongst various reasons, impaired sperm function is the main cause for male infertility. Furthermore, mitochondrial dysfunction and oxidative stress due to increased ROS production, particularly of mitochondrial origin, are believed to be main contributors. Recent Advances: Mitochondrial dysfunction, particularly due to increased ROS production, has often been linked to impaired sperm function/quality. For decades different methods and approaches have been developed to assess mitochondrial features that might correlate with sperm functionality. This connection is now completely accepted, with mitochondrial functionality assessment used more commonly as a readout of sperm functionality. More recently, mitochondria-targeted compounds are on the frontline for both assessment as well as therapeutic approaches. CRITICAL ISSUES In this review we summarize the current methods for assessing key mitochondrial parameters known to reflect sperm quality as well as therapeutic strategies using mitochondrial-targeted antioxidants aiming to improve sperm function in various situations, particularly after sperm cryopreservation. FUTURE DIRECTIONS Although more systematic research is needed, mitochondrial-targeted compounds definitely represent a promising tool to assess as well as to protect and improve sperm function. |
| Databáze: | OpenAIRE |
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