Mathematical modeling of chemotaxis guided amoeboid cell swimming

Autor: Qixuan Wang, Hao Wu
Rok vydání: 2021
Předmět:
food.ingredient
q-bio.TO
Biophysics
finite volume method
reaction-diffusion-convection equation
Models
Biological
Amoeba (genus)
03 medical and health sciences
0302 clinical medicine
food
Engineering
Structural Biology
Models
Rheotaxis
Amoeboid cell
reaction–
Dictyostelium
Tissues and Organs (q-bio.TO)
convection equation
Molecular Biology
Swimming
030304 developmental biology
Cell deformation
0303 health sciences
Chemistry
Chemotaxis
Computational Biology
Quantitative Biology - Tissues and Organs
Cell Biology
Biological Sciences
Biological
diffusion–
amoeboid cell swimming
Infectious Diseases
Emerging Infectious Diseases
FOS: Biological sciences
Physical Sciences
reaction–diffusion–convection equation
bacterial rheotaxis
low Reynolds number swimming
030217 neurology & neurosurgery
Dilute suspension
Zdroj: Physical biology, vol 18, iss 4
ISSN: 1478-3975
Popis: Cells and microorganisms adopt various strategies to migrate in response to different environmental stimuli. To date, many modeling research has focused on the crawling-based Dictyostelium discoideum (Dd) cells migration induced by chemotaxis, yet recent experimental results reveal that even without adhesion or contact to a substrate, Dd cells can still swim to follow chemoattractant signals. In this paper, we develop a modeling framework to investigate the chemotaxis induced amoeboid cell swimming dynamics. A minimal swimming system consists of one deformable Dd amoeboid cell and a dilute suspension of bacteria, and the bacteria produce chemoattractant signals that attract the Dd cell. We use the mathematical amoeba model to generate Dd cell deformation and solve the resulting low Reynolds number flows, and use a moving mesh based finite volume method to solve the reaction–diffusion–convection equation. Using the computational model, we show that chemotaxis guides a swimming Dd cell to follow and catch bacteria, while on the other hand, bacterial rheotaxis may help the bacteria to escape from the predator Dd cell.
Databáze: OpenAIRE
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