Mathematical modeling of chemotaxis guided amoeboid cell swimming
Autor: | Qixuan Wang, Hao Wu |
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Rok vydání: | 2021 |
Předmět: |
food.ingredient
q-bio.TO Biophysics finite volume method reaction-diffusion-convection equation Models Biological Amoeba (genus) 03 medical and health sciences 0302 clinical medicine food Engineering Structural Biology Models Rheotaxis Amoeboid cell reaction– Dictyostelium Tissues and Organs (q-bio.TO) convection equation Molecular Biology Swimming 030304 developmental biology Cell deformation 0303 health sciences Chemistry Chemotaxis Computational Biology Quantitative Biology - Tissues and Organs Cell Biology Biological Sciences Biological diffusion– amoeboid cell swimming Infectious Diseases Emerging Infectious Diseases FOS: Biological sciences Physical Sciences reaction–diffusion–convection equation bacterial rheotaxis low Reynolds number swimming 030217 neurology & neurosurgery Dilute suspension |
Zdroj: | Physical biology, vol 18, iss 4 |
ISSN: | 1478-3975 |
Popis: | Cells and microorganisms adopt various strategies to migrate in response to different environmental stimuli. To date, many modeling research has focused on the crawling-based Dictyostelium discoideum (Dd) cells migration induced by chemotaxis, yet recent experimental results reveal that even without adhesion or contact to a substrate, Dd cells can still swim to follow chemoattractant signals. In this paper, we develop a modeling framework to investigate the chemotaxis induced amoeboid cell swimming dynamics. A minimal swimming system consists of one deformable Dd amoeboid cell and a dilute suspension of bacteria, and the bacteria produce chemoattractant signals that attract the Dd cell. We use the mathematical amoeba model to generate Dd cell deformation and solve the resulting low Reynolds number flows, and use a moving mesh based finite volume method to solve the reaction–diffusion–convection equation. Using the computational model, we show that chemotaxis guides a swimming Dd cell to follow and catch bacteria, while on the other hand, bacterial rheotaxis may help the bacteria to escape from the predator Dd cell. |
Databáze: | OpenAIRE |
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