Effects of Orally Administered 5-Fluorouracil and Its Derivative 5′-Deoxy-5-fluorouridine on 7,12-Dimethylbenz[β]Anthracene-Induced Breast Carcinomas in Rats
| Autor: | Kunio Uematsu, H. Odagiri, Yukio Sawada, Takashi Shimoyama, Tadatsugu Ohno |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
9 10-Dimethyl-1 2-benzanthracene medicine.medical_treatment Pyrimidine-nucleoside phosphorylase Administration Oral DMBA Biochemistry Oral administration Internal medicine Mitotic Index medicine Animals Pentosyltransferases Chemotherapy business.industry Biochemistry (medical) Mammary Neoplasms Experimental Pyrimidine Phosphorylases Rats Inbred Strains Histology Cell Biology General Medicine Chromatin Rats Pyrimidine-nucleoside phosphorylase activity Microscopy Electron Endocrinology Fluorouracil Vacuoles Female Floxuridine Breast carcinoma business medicine.drug |
| Zdroj: | Journal of International Medical Research. 19:249-270 |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Antitumour activity of 20 mg/kg 5-fluorouracil (5-FU) and 100 or 200 mg/kg 5′-deoxy-5-fluorouridine (5′-DFUR) was assessed by tumour regression, light and electron microscopic changes, and immunohistochemical variations in broxuridine labelling in 7,12-dimethylbenz[β]anthracene- (DMBA-) induced breast carcinomas in rats. The relative regression of tumours was significantly ( P < 0.05) greater in animals receiving 5-FU or 5′-DFUR than in control animals. Light microscopic changes became apparent after 3 or 4 days' treatment and were more evident after 4–21 days. Electron microscopic degeneration of tumours was observed after 1 day. The broxuridine labelling index decreased significantly ( P < 0.05) in rats receiving 5-FU and especially in those receiving 5′-DFUR. Concentrations of 5-FU in DMB A-induced breast carcinomas were significantly ( P < 0.05) higher in rats treated with 5′-DFUR than in those treated with 5-FU, and the histological degeneration was significantly ( P < 0.05) more advanced in 5′-DFUR-than in 5-FU-treated animals, possibly due to the higher pyrimidine nucleoside phosphorylase activity in the former treatment group. |
| Databáze: | OpenAIRE |
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