Association of Ang-2, vWF, and EVLWI with risk of mortality in sepsis patients with concomitant ARDS: A retrospective study
| Autor: | Kai Wang, Guang Sun, Shi-Fu Wang, Lei Wang, Shou-jun Wang, Rumin Zhang, Yong Yu, Shuang Ma, Yi-Feng Yue, Wei-Ping Zhang, Lin Wang, Rong-Qing Sun, Hong-Chang Zhu, Hong-Qiang Xie, Meiling Zhao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
ARDS Von Willebrand factor law.invention Angiopoietin-2 Sepsis 03 medical and health sciences 0302 clinical medicine Risk Factors law Internal medicine medicine Risk of mortality Humans Retrospective Studies Respiratory Distress Syndrome lcsh:R5-920 APACHE II business.industry Area under the curve Retrospective cohort study General Medicine Prognosis medicine.disease Intensive care unit ROC Curve Extravascular lung water index 030220 oncology & carcinogenesis Concomitant Extravascular Lung Water 030211 gastroenterology & hepatology lcsh:Medicine (General) business |
| Zdroj: | Journal of the Formosan Medical Association, Vol 119, Iss 5, Pp 950-956 (2020) |
| ISSN: | 0929-6646 |
| Popis: | Background/Purpose This study aimed to determine the potential effects of angiopoietin-2 (Ang-2), von Willebrand factor (vWF), and extravascular lung water index (EVLWI) on the risk of mortality in sepsis patients with concomitant acute respiratory distress syndrome (ARDS). Methods This retrospective study recruited 41 sepsis patients with concomitant ARDS from January 2015 to June 2018. Data of Ang-2 and vWF levels, EVLWI, and sequential organ failure assessment scores were collected at 0, 24, and 48 h after admission to the hospital. Results The length of intensive care unit stay (P = 0.041) and Acute Physiology and Chronic Health Evaluation-2 (APACHE II) score (P = 0.003) were associated with the risk of mortality. Furthermore, increased Ang-2 levels and EVLWI at 24 h and 48 h were associated with an increased risk of mortality. Moreover, the APACHE II score at hospital admission significantly predicted the risk of mortality (area under the curve [AUC], 0.834; 95% confidence interval [CI], 0.665–0.983). Finally, the models containing a combination of Ang-2 level and EVLWI at 24 h (AUC, 0.908; 95% CI, 0.774–0.996) and Ang-2 level and EVLWI at 48 h (AUC, 0.981; 95% CI, 0.817–1.000) had high diagnostic values for predicting risk of mortality. Conclusion The study findings indicate that Ang-2 levels and EVLWI at 24 h and 48 h after admission are significantly associated with the risk of mortality. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|