Continuous positive airway pressure deepens sleep in patients with Alzheimer’s disease and obstructive sleep apnea
| Autor: | Jana R. Cooke, Loki Natarajan, Jose S. Loredo, Jody Corey-Bloom, Lianqi Liu, Barton S. Palmer, Feng He, Sonia Ancoli-Israel |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Time Factors Polysomnography medicine.medical_treatment Sleep REM Comorbidity Placebo Article Alzheimer Disease medicine Humans Continuous positive airway pressure Aged Aged 80 and over Sleep Apnea Obstructive Sleep Stages Continuous Positive Airway Pressure medicine.diagnostic_test business.industry Sleep apnea General Medicine medicine.disease Sleep in non-human animals Circadian Rhythm Obstructive sleep apnea Treatment Outcome Anesthesia Female Sleep onset Arousal business |
| Zdroj: | Sleep Medicine. 10:1101-1106 |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2008.12.016 |
| Popis: | Objective Patients with Alzheimer’s disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA. Methods A randomized placebo-controlled trial of 3 weeks of therapeutic CPAP (tCPAP) vs. 3 weeks placebo CPAP (pCPAP) followed by 3 weeks tCPAP in patients with AD and OSA. Polysomnography data from screening after one night and after 3 weeks of treatment were analyzed. Records were scored for percent of each sleep stage, total sleep time (TST), sleep efficiency (SE), sleep period (SP), time in bed (TIB), sleep onset (SO), wake time after sleep onset (WASO), and arousals. A randomized design comparing one night of pCPAP to tCPAP and a paired analysis combining 3 weeks of tCPAP were performed. Results Fifty-two participants (mean age = 77.8 years, SD = 7.3) with AD and OSA were included. After one treatment night, the tCPAP group had significantly less % Stage 1 ( p = 0.04) and more % Stage 2 sleep ( p = 0.02) when compared to the pCPAP group. In the paired analysis, 3 weeks of tCPAP resulted in significant decreases in WASO ( p = 0.005), % Stage 1 ( p = 0.001), arousals ( p = 0.005), and an increase in % Stage 3 ( p = 0.006). Conclusion In mild to moderate AD patients with OSA, the use of tCPAP resulted in deeper sleep after just one night, with improvements maintained for 3 weeks. |
| Databáze: | OpenAIRE |
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