Reduced progression of diabetic retinopathy after islet cell transplantation compared with intensive medical therapy
| Autor: | Stephen K. N. Ho, R. Mark Meloche, Michelle Fung, David M. Thompson, Paul Keown, Graydon S. Meneilly, Sharon E. Kozak, Keith G. Dawson, Mohammed Al Mehthel, Zilaing Ao, R. Jean Shapiro, Iain S. Begg, Garth L. Warnock, Khalid Al Ghofaili, Loay Al Riyami, Suet On Tong, Claire Harris |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Islets of Langerhans Transplantation Visual Acuity Macular Edema Cohort Studies Internal medicine Diabetes mellitus medicine Humans Diabetic Nephropathies Prospective Studies Prospective cohort study Aged Glycated Hemoglobin Transplantation Type 1 diabetes geography Islet cell transplantation geography.geographical_feature_category Cross-Over Studies Diabetic Retinopathy business.industry Diabetic retinopathy Middle Aged medicine.disease Islet Surgery Diabetes Mellitus Type 1 Disease Progression Female business Retinopathy |
| Zdroj: | Transplantation. 85(10) |
| ISSN: | 0041-1337 |
| Popis: | BACKGROUND Diabetic retinopathy is a major complication of type 1 diabetes and remains a leading cause of visual loss. There have been no comparisons of the effectiveness of intensive medical therapy and islet cell transplantation on preventing progression of diabetic retinopathy. METHODS The British Columbia islet transplant program is conducting a prospective, crossover study comparing medical therapy and islet cell transplantation on the progression of diabetic retinopathy. Progression was defined as the need for laser treatment or a one step worsening along the international disease severity scale. An interim data analysis was performed after a mean 36-month follow-up postislet transplantation and these results are presented. RESULTS The medical and postislet transplant groups were similar at baseline. Subjects after islet transplantation had better glucose control than the medically treated subjects (mean HbA1c 6.7%+/-0.9% vs. 7.5+/-1.2, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|