Relationship and sexual experiences in women with early‐onset oestrogen deficiency: Comparison between women with Turner syndrome and premature ovarian insufficiency
Autor: | Davina Puri, Hazel Isabella Learner, Carol Cardona Attard, Vikram Sinai Talaulikar, Lih-Mei Liao, Antoinette Cameron-Pimblett, Clementina La Rosa, Gerard S. Conway, Melanie C. Davies |
---|---|
Rok vydání: | 2020 |
Předmět: |
Adult
Delayed puberty medicine.medical_specialty Endocrinology Diabetes and Metabolism Population Hypoestrogenism Turner Syndrome 030209 endocrinology & metabolism Primary Ovarian Insufficiency Premature ovarian insufficiency 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Turner syndrome Humans Medicine education education.field_of_study business.industry Obstetrics Puberty Hazard ratio Infant Newborn Estrogens medicine.disease Confidence interval Sexual intercourse Cross-Sectional Studies 030220 oncology & carcinogenesis Female medicine.symptom business |
Zdroj: | Clinical Endocrinology. 93:473-481 |
ISSN: | 1365-2265 0300-0664 |
Popis: | Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess relationship and sexual experiences comparing women with TS and premature ovarian insufficiency (POI).Cross-sectional observational study.302 women with TS and 53 women with karyotypically normal POI (median age 33.0 [15.0-78.4] and 26.3 [17.8-52.3], respectively).A self-reporting questionnaire was used to collect data on relationship and sexual experiences.Women with TS were older than women with POI (P = .002). Compared to women with POI, a smaller proportion of women with TS had ever had vaginal sexual intercourse (VSI) (40 [78.4%] vs 169 [58.1%], respectively, P = .006) and women with TS exhibited a delay in the median age at first relationship and VSI (POI 19.3 ± 0.4 vs TS 22.2 ± 1.1, P = .001). Start of oestrogen replacement therapy at ≤ 14 years of age compared with 14 years did not result in earlier relationship and sexual debut. After adjusting for age and diagnosis, induction of puberty, as opposed to spontaneous puberty, was associated with a delay in the median age at first relationship and VSI and a reduced probability of having VSI (Hazard ratio = 0.44 [95% confidence interval: 0.32-0.60], P = .001).Turner syndrome and induction of puberty are associated with a reduced likelihood and a delay in relationship and sexual experiences. Women needing puberty induction and women with TS more than POI have a delayed mean age at first VSI compared to the general population. |
Databáze: | OpenAIRE |
Externí odkaz: |