Perfusion and diffusion limitations in middle ear gas exchange: The exchange of CO2 as a test case
| Autor: | Yael Marcusohn, Amos Ar, Joris J.J. Dirckx |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cardiac output
Diffusion Analytical chemistry Ear Middle Context (language use) Body weight Rats Sprague-Dawley medicine Animals Body Size Cardiac Output Biology Mucous Membrane Chemistry Physics Models Cardiovascular Biological Transport Carbon Dioxide Sensory Systems Rats Perfusion medicine.anatomical_structure Regional Blood Flow Middle ear Gases Rabbits |
| Zdroj: | Hearing research |
| ISSN: | 0378-5955 |
| Popis: | A long standing debate on perfusion/diffusion limitations in the context of middle ear (ME) gas exchange was revisited using data obtained from previous iso-pressure gas-exchange measurements in different mammals. We tried to determine whether the exchange of CO2 in the ME is limited by perfusion or by diffusion by comparing the mass specific cardiac output ( ms Q ˙ ) and the mass specific initial CO2 flow rate into air-washed MEs ( ms V i ˙ CO 2 ) of rabbits and rats. Based on previously published allometry at rest, the ms Q ˙ was 0.154 mL/(min g) in rabbits (mean body weight: 2800 g) and 0.259 mL/(min g) in rats (mean body weight: 179.1 g); ms V i ˙ CO 2 (Δt = 0) was 0.109 ± 0.047 μL/(h g) in rabbits (n = 16) and 0.170 ± 0.094 μL/(h g) in rats (n = 9). Similar ratios were found when an allometric comparison was made between the ratio of ms V i ˙ CO 2 (Δt = 0) (∼0.64), and the ratio of ms Q ˙ s (∼0.59) in rabbits and rats. If the active mucosal surface areas of MEs of rabbits and rats are directly proportional to their masses as are the masses of their hearts and if their ms Q ˙ s are proportional to the rates of blood flows in the ME mucosa, these results support the assumption that the exchange of CO2 in the ME of mammals is mainly perfusion (and not diffusion) dependent. |
| Databáze: | OpenAIRE |
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