FIBROBLAST GROWTH FACTOR 23 AND KLOTHO PROTEIN IN THE PATHOGENESIS OF SECONDARY HYPERPARATHYROIDISM

Autor:	M I Arbuzova, A V Ilin
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Fibroblast growth factor 23 гемодиализ Osteopathy business.industry RZ301-397.5 хронические заболевания почек medicine.disease urologic and male genital diseases вторичный гиперпаратиреоз паратиреоидный гормон Pathogenesis medicine Cancer research Secondary hyperparathyroidism business Klotho
Zdroj:	Остеопороз и остеопатии, Vol 16, Iss 3, Pp 20-27 (2013)
ISSN:	2311-0716 2072-2680
Popis:	One of the main problems in patients with chronic kidney disease (CKD) is a disturbance of calcium-phosphorus metabolism, especially in chronic hemodialysis. Besides classical endocrine axis parathyroid-kidney, in recent years was established the existence of a new endocrine axis the bone-kidney, which gives a better explanation of the calcium and phosphorus metabolism abnormalities, pathophysiology of secondary hyperparathyroidism in CKD. FGF23 is a circulating factor synthesized in osteocytes. It inhibits renal phosphate reabsorption and activity of 1-alphahydroxylase. Anti-aging Klotho protein is a potent co-factor of FGF23. This review presents the mechanisms of the interaction of these elements of the newly discovered axis in normal settings and secondary hyperparathyroidism.
Databáze:	OpenAIRE
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