Antibody avidity, persistence, and response to antigen recall: comparison of vaccine adjuvants
| Autor: | Mohamed El Idrissi, Sonia Budroni, Patricia Bourguignon, Arnaud Marchant, Michel Janssens, Oretta Finco, Magalie Caubet, Wivine Burny, Gianfranco Volpini, Ugo D'Oro, Geert Leroux-Roels, Pierre Van Damme, Nathalie Garçon, Tino F. Schwarz, Robbert van der Most, Andrea Cavallone, Arnaud M. Didierlaurent, Francesca Buricchi, Vincent Dewar |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Adaptive immunity chemical and pharmacologic phenomena Biology Article 03 medical and health sciences 0302 clinical medicine Medical research Antigen medicine Pharmacology (medical) Avidity 030212 general & internal medicine AS03 Memory B cell B cell RC254-282 Pharmacology Vaccines Neoplasms. Tumors. Oncology. Including cancer and carcinogens Généralités Hepatitis B RC581-607 Translational research medicine.disease 030104 developmental biology Infectious Diseases medicine.anatomical_structure biology.protein Human medicine Antibody Immunologic diseases. Allergy Adjuvant |
| Zdroj: | NPJ vaccines, 6 (1 NPJ Vaccines npj Vaccines npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2059-0105 |
| Popis: | Differences in innate immune ‘imprinting’ between vaccine adjuvants may mediate dissimilar effects on the quantity/quality of persisting adaptive responses. We compared antibody avidity maturation, antibody/memory B cell/CD4+ T cell response durability, and recall responses to non-adjuvanted fractional-dose antigen administered 1-year post-immunization (Day [D]360), between hepatitis B vaccines containing Adjuvant System (AS)01B, AS01E, AS03, AS04, or Alum (NCT00805389). Both the antibody and B cell levels ranked similarly (AS01B/E/AS03 > AS04 > Alum) at peak response, at D360, and following their increases post-antigen recall (D390). Proportions of high-avidity antibodies increased post-dose 2 across all groups and persisted at D360, but avidity maturation appeared to be more strongly promoted by AS vs. Alum. Post-antigen recall, frequencies of subjects with high-avidity antibodies increased only markedly in the AS groups. Among the AS, total antibody responses were lowest for AS04. However, proportions of high-avidity antibodies were similar between groups, suggesting that MPL in AS04 contributes to avidity maturation. Specific combinations of immunoenhancers in the AS, regardless of their individual nature, increase antibody persistence and avidity maturation. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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