Fluvoxamine in prevention of relapse in bulimia nervosa: effects on eating-specific psychopathology
| Autor: | Robert L Holland, Winfried Rief, Jutta Dohne, Ralf Krüger, Manfred M. Fichter |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
medicine.medical_specialty Self-Assessment Patient Dropouts Adolescent Fluvoxamine Anorexia Relapse prevention law.invention Randomized controlled trial Double-Blind Method law Recurrence mental disorders medicine Body Image Humans Pharmacology (medical) Bulimia Psychiatry Psychiatric Status Rating Scales Bulimia nervosa Feeding Behavior Middle Aged medicine.disease Eating Disorder Inventory Psychiatry and Mental health Eating disorders Antidepressive Agents Second-Generation medicine.symptom Psychology Clinical psychology medicine.drug Psychopathology |
| Zdroj: | Journal of clinical psychopharmacology. 16(1) |
| ISSN: | 0271-0749 |
| Popis: | In a double-blind, placebo-controlled study of 72 patients with bulimia nervosa treated successfully with inpatient psychotherapy, the efficacy of fluvoxamine in maintaining improvement was tested. Fluvoxamine and placebo, respectively, were given over a period of about 15 weeks (2-3 weeks inpatient titration phase, 12 weeks outpatient relapse-prevention [maintenance] phase). The variables assessed concerned bulimic behavior and other aspects of eating disorders, global status, depression, anxieties, obsessive-compulsive behavior, and other aspects of psychopathology. Because the dropout rate was relatively high (N = 27 [33%]) and because it was considerably higher in the fluvoxamine group (19 out of 37 subjects), analyses were performed on the intent-to-treat sample (ideally including all 72 subjects). Results of the completer sample analyses (including only those subjects who finished the study) are briefly presented for comparison. In both the intent-to-treat and the completer analyses, the following scales showed fluvoxamine to have a significant effect in reducing the return of bulimic behavior: (1) self-ratings: Eating Disorder Inventory (EDI)-bulimia, urges to binge in previous week and the number of actual binges in the previous week; (2) expert ratings: Psychiatric Status Rating Scales for Bulimia nervosa, Structured Interview for Anorexia and Bulimia nervosa (SIAB)-"total score," SIAB-subscale "fasting," and SIAB-subscale "vomiting." Two further variables (EDI-total score and SIAB-subscale "bulimia") showed the superior relapse prevention effects of fluvoxamine compared with placebo for the completer sample, while they did not reach significance for group-by-time interactions in the intent-to-treat sample. During a final, short (4-week) off-medication phase, no effect of the discontinuation of medication was observed. |
| Databáze: | OpenAIRE |
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