3′-Terminal nucleotide sequences in the genome RNA of picornaviruses

Autor:	Alan George Porter, Fred Brown, Harris T J R, David J. Rowlands, D. N. Black, Peter Fellner
Rok vydání:	1978
Předmět:	chemistry.chemical_classification Genetics Untranslated region Signal peptide Multidisciplinary Base Sequence Picornavirus biology viruses RNA Picornaviridae biology.organism_classification Genome Virus Poliovirus chemistry RNA Viral Nucleotide Binding site Poly A
Zdroj:	Nature. 276:298-301
ISSN:	1476-4687 0028-0836
DOI:	10.1038/276298a0
Popis:	IN common with eukaryotic cellular mRNAs1–3, the terminal sequences in virus RNAs contain untranslated regions of variable length4–11. These regions are likely to contain binding sites for macromolecules involved in functions such as replication4 and translation4–6 of the RNA, and assembly of virus particles. We report here that, as a first step in identifying these sites we have sequenced between 33 and 156 nucleotides next to the 3′-terminal poly(A)12–14 of representative viruses from three of the four picornavirus genera15, the enteroviruses, cardioviruses and foot-and-mouth disease viruses (FMDV). The viruses chosen for these analyses allow us to make comparisons of the 3′-terminal sequences both within and between the three genera. Within each genus the 3′-terminal sequences are at least 60% homologous, whereas viruses from different genera show little similarity. The 3′-terminal sequences also show some unexpected features, including the lack of the putative signal sequence 5′-AAUAAA-3′ (ref. 1) in viruses from two genera.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee922667aa5c7c1f0d14be7d4fa93379 https://doi.org/10.1038/276298a0 Zobrazit plný text záznamu