The role of 99mTc-MIBI SPECT/CT in patients with secondary hyperparathyroidism: comparison with 99mTc-MIBI planar scintigraphy and ultrasonography
| Autor: | Wan-Ru Li, Qiong Zou, Ting Ye, Ju Jiao, Ting Yang, Yin-Qian Kang, Yong Zhang, Lei Xu, shu-qin jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Technetium Tc 99m Sestamibi Single Photon Emission Computed Tomography Computed Tomography lcsh:Medical technology Missed diagnosis Sensitivity and Specificity 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences 0302 clinical medicine Sensitivity Maximum diameter Humans Medicine Radiology Nuclear Medicine and imaging In patient Radionuclide Imaging Retrospective Studies Ultrasonography business.industry Significant difference Planar scintigraphy Middle Aged medicine.disease Secondary hyperparathyroidism lcsh:R855-855.5 030220 oncology & carcinogenesis 99mtc-MIBI SPECT/CT Female Hyperparathyroidism Secondary medicine.symptom business Nuclear medicine Research Article |
| Zdroj: | BMC Medical Imaging, Vol 20, Iss 1, Pp 1-7 (2020) BMC Medical Imaging |
| ISSN: | 1471-2342 |
| DOI: | 10.1186/s12880-020-00517-9 |
| Popis: | Background This study aimed to compare the sensitivity of 99mTc-MIBI SPECT/CT, 99mTc-MIBI planar scintigraphy and ultrasonography (US) in patients with secondary hyperparathyroidism (SHPT), and to explore the factors that affect the sensitivity of 99mTc-MIBI SPECT/CT. Methods In this retrospective study, forty-six patients with SHPT who underwent 99mTc-MIBI planar scintigraphy, 99mTc-MIBI SPECT/CT and US were enrolled. They underwent surgery within 1 month. We compared the sensitivity of the different imaging methods based on the lesions according to the pathological results. The parathyroid lesions on 99mTc-MIBI SPECT/CT images were divided into missed diagnosis group (MDG) and non-missed diagnosis group (NMDG). We compared the lesion to background ratio (LBR), maximum diameter, volume, the mean CT Hounsfield unit values (CTmean) and location of lesions between MDG and NMDG. Results The sensitivity of 99mTc-MIBI SPECT/CT, 99mTc-MIBI planar scintigraphy and US were 70.30% versus 48.48% versus 61.82%, respectively. The sensitivity of 99mTc-MIBI SPECT/CT combined US was 79.39%, which was higher than 99mTc-MIBI SPECT/CT with significant difference (P = 0.000). On 99mTc-MIBI SPECT/CT images, the LBR, maximum diameter and volume of lesions in MDG was smaller than those in NMDG with significant difference (P 3 versus 6.75 ± 5.08, 15.03 ± 4.94 mm and 863.85 ± 1216.0 mm3, respectively. Conclusions 99mTc-MIBI SPECT/CT exhibited the highest sensitivity among the three methods. When 99mTc-MIBI SPECT/CT combined with US, the sensitivity can be further improved. Lesions with lower MIBI uptake and smaller lesions on 99mTc-MIBI SPECT/CT images were easily missed. |
| Databáze: | OpenAIRE |
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