Impact of KCNQ1, CDKN2A/2B, CDKAL1, HHEX, MTNR1B, SLC30A8, TCF7L2, and UBE2E2 on risk of developing type 2 diabetes in Thai population

Autor: Watip Tangjittipokin, Mayuree Homsanit, Nattachet Plengvidhya, Chutima Chanprasert, Pa-thai Yenchitsomanus, Nalinee Chongjaroen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
endocrine system diseases
Genome-wide association study
chemistry.chemical_compound
Medicine
Genetics (clinical)
tRNA Methyltransferases
Type 2 diabetes
Middle Aged
Prognosis
Thailand
Association study
KCNQ1 Potassium Channel
Population study
Female
Transcription Factor 7-Like 2 Protein
Adult
medicine.medical_specialty
lcsh:Internal medicine
Genotype
lcsh:QH426-470
Single-nucleotide polymorphism
Zinc Transporter 8
Thai population
Polymorphism
Single Nucleotide
03 medical and health sciences
Population Groups
Internal medicine
Genetics
Cyclin-Dependent Kinase Inhibitor p18
Humans
Genetic Predisposition to Disease
lcsh:RC31-1245
CDKAL1
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p15
Genetic association
Homeodomain Proteins
Receptor
Melatonin
MT2
business.industry
nutritional and metabolic diseases
Odds ratio
Single nucleotide polymorphisms
lcsh:Genetics
030104 developmental biology
Diabetes Mellitus
Type 2
chemistry
Case-Control Studies
Ubiquitin-Conjugating Enzymes
Glycated hemoglobin
business
TCF7L2
Biomarkers
Follow-Up Studies
Transcription Factors
Zdroj: BMC Medical Genetics, Vol 19, Iss 1, Pp 1-9 (2018)
ISSN: 1471-2350
DOI: 10.1186/s12881-018-0614-9
Popis: Background Several type 2 diabetes (T2D) susceptibility loci identified via genome-wide association studies were found to be replicated among various populations. However, the influence of these loci on T2D in Thai population is unknown. The aim of this study was to investigate the influence of eight single nucleotide polymorphisms (SNPs) reported in GWA studies on T2D and related quantitative traits in Thai population. Methods Eight SNPs in or near the KCNQ1, CDKN2A/2B, SLC30A8, HHEX, CDKAL1, TCF7L2, MTNR1B, and UBE2E2 genes were genotyped. A case-control association study comprising 500 Thai patients with T2D and 500 ethnically-matched control subjects was conducted. Associations between SNPs and T2D were examined by logistic regression analysis. The impact of these SNPs on quantitative traits was examined by linear regression among case and control subjects. Results Five SNPs in KCNQ1 (rs2237892), CDK2A/2B (rs108116610, SLC30A8 (rs13266634), TCF7L2 (rs7903146) and MTNR1B (rs1387153) were found to be marginally associated with risk of developing T2D, with odds ratios ranging from 1.43 to 2.02 (p = 0.047 to 3.0 × 10–4) with adjustments for age, sex, and body mass index. Interestingly, SNP rs13266634 of SLC30A8 gene reached statistical significance after correcting for multiple testing (p = 0.0003) (p
Databáze: OpenAIRE
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