Prevalence of Airflow Limitation Defined by Pre- and Post-Bronchodilator Spirometry in a Community-Based Health Checkup: The Hisayama Study
| Autor: | Yumiko Ishii, Satoru Fukuyama, Yoichi Nakanishi, Yukari Tajiri-Asai, Hiromasa Inoue, Keiko Kan-o, Naotaka Noda, Yasuko Kaneko, Koichiro Matsumoto, Yutaka Kiyohara, Takako Nakano |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Spirometry medicine.medical_specialty medicine.drug_class Airflow General Biochemistry Genetics and Molecular Biology 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Japan Residence Characteristics Forced Expiratory Volume Internal medicine Bronchodilator Prevalence medicine Humans 030212 general & internal medicine Aged Asthma COPD medicine.diagnostic_test business.industry General Medicine Middle Aged respiratory system Former Smoker medicine.disease Bronchodilator Agents respiratory tract diseases 030228 respiratory system Health Female Pulmonary Ventilation business Airway |
| Zdroj: | The Tohoku Journal of Experimental Medicine. 238:179-184 |
| ISSN: | 1349-3329 0040-8727 |
| Popis: | Spirometry in health checkup may contribute to early diagnosis of chronic obstructive pulmonary disease (COPD) and asthma. Although post-bronchodilator airflow limitation is essential for definite diagnosis of COPD and post-bronchodilator normalization of airflow is suggestive of asthma, this test has not been prevailed in health checkup. The objective of this study was to estimate the prevalence of airflow limitation defined by pre- and post-bronchodilator spirometry in health checkup. Post-bronchodilator spirometry was conducted for participants with airflow limitation in a town-wide health checkup for residents aged 40 years and older in Hisayama, a town in the western part of Japan. The prevalence of pre- and post-bronchodilator airway limitation defined by FEV1/FVC < 70% were estimated. A total of 2,232 participants underwent pre-bronchodilator spirometry. In males, the age of current smokers was significantly younger than those of never smokers and former smokers. In females, the ages of current- and former smokers were significantly younger than never smokers. The values of %FEV1 and %FVC in current smokers were significantly lower than those in former smokers and never smokers. Two hundred sixty nine subjects, 85% of total subjects with a pre-bronchodilator FEV1/FVC < 70%, completed post-bronchodilator spirometry. The prevalence of pre-bronchodilator airflow limitation was 14.6% in males and 13.7% in females, and the prevalence of post-bronchodilator airway limitation was 8.7% and 8.7%, respectively. Post-bronchodilator spirometry in health checkup would reduce the number of subjects with probable COPD to two-third. Recommendation for those examinees to take further evaluations may pave the way for early intervention. |
| Databáze: | OpenAIRE |
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