Inflammatory and oxidative stress biomarkers at protein and molecular levels in workers occupationally exposed to crystalline silica
| Autor: | Daniela Gnoatto, Gabriela Göethel, Jorge Souza, Elisa Sauer, Nuryan Fão, Jessica Nardi, Solange Cristina Garcia, Larissa Cestonaro, Caroline Peruzzi, Sabrina Nascimento, Bruna Gauer, Shanda Cattani, Cristiane Paim |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Health Toxicology and Mutagenesis Lymphocyte Chemokine CXCL2 Silicosis Physiology Gene Expression 010501 environmental sciences medicine.disease_cause 01 natural sciences Mining Pathogenesis chemistry.chemical_compound Malondialdehyde Occupational Exposure medicine Environmental Chemistry Humans Interleukin 8 L-Selectin Lung cancer 0105 earth and related environmental sciences Inflammation biology business.industry Interleukin-8 General Medicine medicine.disease Genes p53 Silicon Dioxide Pollution Oxidative Stress medicine.anatomical_structure chemistry Case-Control Studies biology.protein L-selectin business Oxidative stress Biomarkers Heme Oxygenase-1 |
| Zdroj: | Environmental science and pollution research international. 26(2) |
| ISSN: | 1614-7499 |
| Popis: | Workers chronically exposed to respirable crystalline silica (CS) are susceptible to adverse health effects like silicosis and lung cancer. This study aimed to investigate potential early peripheral biomarkers of inflammation and oxidative stress in miners. The subjects enrolled in this study were occupationally unexposed workers (OUW, n = 29) and workers exposed to crystalline silica (WECS), composed by miners, which were divided into two subgroups: workers without silicosis (WECS I, n = 39) and workers diagnosed with silicosis, retired from work (WECS II, n = 42). The following biomarkers were evaluated: gene expression of L-selectin, CXCL2, CXCL8 (IL-8), HO-1, and p53; malondialdehyde (MDA) plasma levels and non-protein thiol levels in erythrocytes. Additionally, protein expression of L-selectin was evaluated to confirm our previous findings. The results demonstrated that gene expression of L-selectin was decreased in the WECS I group when compared to the OUW group (p |
| Databáze: | OpenAIRE |
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