Effect of Electric Convulsion Therapy on Urinary Excretion of 3', 5' Cyclic Adenosine Monophosphate
| Autor: | Dennis V. Parke, Kamel Hamadah, Helen Holmes, Gordon C. Hartman, G. B. Barker |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Brain tissue chemistry.chemical_compound Electroconvulsive therapy Urinary excretion Internal medicine Convulsion Cyclic AMP medicine Humans Cyclic adenosine monophosphate Electroconvulsive Therapy Depressive symptoms General Environmental Science Depression business.industry General Engineering Brain Papers and Originals General Medicine Middle Aged Endocrinology chemistry General Earth and Planetary Sciences Antidepressant Female medicine.symptom business |
| Zdroj: | BMJ. 3:439-441 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.3.5824.439 |
| Popis: | Electric convulsion therapy (E.C.T.) was used in the treatment of 13 women inpatients suffering from depressive symptoms. Twelve of the patients showed a significant increase in urinary excretion of 3′, 5′ cyclic adenosine monophosphate (cAMP) on the day of treatment, whereas four controls who received all or part of the preliminary treatment but no electric shock showed a reduction. The results of this study are consistent with the hypothesis that the antidepressant action of E.C.T. is mediated through an increased production of cAMP in brain tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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