Antiretroviral therapy targeting HIV-1 viral infectivity factor; in silico approach
| Autor: | Muriira G Karau, Bundi P Karau |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Antigenicity biology business.industry viruses In silico virus diseases biochemical phenomena metabolism and nutrition Virology Viral infectivity factor Virus Protein structure Infectious Diseases Ubiquitin Poster Presentation biology.protein Medicine Antibody business lcsh:RC581-607 APOBEC3G |
| Zdroj: | Retrovirology Retrovirology, Vol 6, Iss Suppl 2, p P45 (2009) |
| ISSN: | 1742-4690 |
| Popis: | Background The HIV-1 viral infectivity factor (VIF) binds to the host defense factor human APOBEC3G (hA3G) and prevents its assembly with viral particles and mediates its elimination. VIF binds Elongin B/C complex of the ubiquitination machinery and it also forms multimers. Knowledge of the surface accessibility by solvents and other proteins and antigenicity is important in designing B and T cell epitopes that could be used as antiretroviral drugs and vaccine to block the activity of Vif. Inactivation of Vif supports the role of hA3G in inhibiting in vivo replication of the virus. |
| Databáze: | OpenAIRE |
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