Alpha-Fetoprotein-Producing Rectal Carcinoma. A Case Report
| Autor: | Jun Sueda, Genzan Shirouzu, Jun Taguchi, Ken Hashimoto, Masamichi Kojiro, Hirohisa Yano, Rin Yamaguchi |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Pathology medicine.medical_specialty Medullary cavity Rectal Neoplasms Liver Neoplasms Rectum General Medicine Adenocarcinoma Biology medicine.disease digestive system diseases Metastasis medicine.anatomical_structure Trabecular Pattern embryonic structures medicine Carcinoma Humans alpha-Fetoproteins Yolk sac Alpha-fetoprotein Aged |
| Zdroj: | The Kurume Medical Journal. 44:339-348 |
| ISSN: | 1881-2090 0023-5679 |
| DOI: | 10.2739/kurumemedj.44.339 |
| Popis: | A case with an alpha-fetoprotein (AFP)-producing carcinoma originating from the rectum is described. A 71-year-old male patient, who underwent a rectectomy for rectal carcinoma, developed space occupying lesions in the liver and a remarkable AFP elevation (220,000 ng/ml) in the 6th month postoperatively, and then expired one year later. Histologically, the rectal carcinoma consisted of well-differentiated adenocarcinomas, and contiguous cancerous cells proliferating in either a medullary or trabecular pattern. In the "trabecular" areas, localization of AFP was confirmed immunohistochemically. Results of concanavalin A or lens culinaris agglutinin affinity chromatography demonstrated that it was between a hepatic type and a yolk sac type, and was considered to be an intestinal type. This could have been an AFP-producing rectal carcinoma, in which the patient experienced liver metastasis at a relatively early postoperative period and died. This shows that AFP-producing rectal carcinomas are highly malignant, biologically, similar to AFP-producing gastric cancers. |
| Databáze: | OpenAIRE |
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