MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world
| Autor: | Raheel Qamar, Atika Mansoor, Bushra Mirza, Kehkashan Mazhar, Shazia Micheal, Saima Siddiqi, Noor Ullah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Infertility Genotype Folate Metabolism Homozygous genotype Physiology 030105 genetics & heredity Polymorphism Single Nucleotide White People Male infertility 03 medical and health sciences Folic Acid 0302 clinical medicine Gene Frequency Risk Factors Humans Medicine Genetic Predisposition to Disease Pakistan Socioeconomic status Alleles Infertility Male Methylenetetrahydrofolate Reductase (NADPH2) Pharmacology biology business.industry General Medicine medicine.disease Minor allele frequency Social Class Case-Control Studies 030220 oncology & carcinogenesis Meta-analysis Methylenetetrahydrofolate reductase biology.protein Molecular Medicine business |
| Zdroj: | Personalized Medicine. 16:35-49 |
| ISSN: | 1744-828X 1741-0541 |
| DOI: | 10.2217/pme-2018-0045 |
| Popis: | Aim: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Methodology & results: Male infertility association of C665T and A1298C polymorphisms was explored, this topic is still debatable. Infertile men (232) and controls (114) were genotyped and statistically analyzed. Comparison of patients (6180) and controls (5744) of Caucasian populations was performed by meta-analysis. Pooled results showed A1298C minor allele and homozygous genotype to be of a significantly higher frequency in the low-income group. Increase in per capita income has shown an increasing trend in the minor allele frequency in various world populations, potentially due to dietry-folate compensation. Conclusion: A1298C seems more relevant marker than C665T for infertility association in Caucasian populations and may be addressed by improving dietary folate. |
| Databáze: | OpenAIRE |
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