Role of liver ICAM-1 in metastasis
| Autor: | Aitor Benedicto, Irene Romayor, Beatriz Arteta |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Liver sinusoid Cancer Research ICAM-1 Angiogenesis Cell adhesion molecule Intercellular Adhesion Molecule-1 Review Biology Intercellular adhesion molecule medicine.disease Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer cell medicine Cancer research |
| Zdroj: | Oncology Letters. 14:3883-3892 |
| ISSN: | 1792-1082 1792-1074 |
| DOI: | 10.3892/ol.2017.6700 |
| Popis: | Intercellular adhesion molecule (ICAM)-1, is a transmembrane glycoprotein of the immunoglobulin (Ig)-like superfamily, consisting of five extracellular Ig-like domains, a transmembrane domain and a short cytoplasmic tail. ICAM-1 is expressed in various cell types, including endothelial cells and leukocytes, and is involved in several physiological processes. Furthermore, it has additionally been reported to be expressed in various cancer cells, including melanoma, colorectal cancer and lymphoma. The majority of studies to date have focused on the expression of the ICAM-1 on the surface of tumor cells, without research into ICAM-1 expression at sites of metastasis. Cancer cells frequently metastasize to the liver, due to its unique physiology and specialized liver sinusoid capillary network. Liver sinusoidal endothelial cells constitutively express ICAM-1, which is upregulated under inflammatory conditions. Furthermore, liver ICAM-1 may be important during the development of liver metastasis. Therefore, it is necessary to improve the understanding of the mechanisms mediated by this adhesion molecule in order to develop host-directed anticancer therapies. |
| Databáze: | OpenAIRE |
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