Distinct Salivary Gland Features in Sjögren's Syndrome and Lupus Erythematosus Sialadenite
| Autor: | Wanessa Siqueira Cavalcante, Marcello Menta Simonsen Nico, Sheyla Batista Bologna, Giovanna Piacenza Florezi, Milena Monteiro de Souza, Silvia Vanessa Lourenço |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Ductal cells Dermatology Salivary Glands Minor Xerostomia Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences symbols.namesake Young Adult 0302 clinical medicine stomatognathic system medicine Humans Lupus Erythematosus Systemic skin and connective tissue diseases Hyaline Fisher's exact test Aged Systemic lupus erythematosus Lupus erythematosus Salivary gland business.industry General Medicine Middle Aged medicine.disease Sialadenitis stomatognathic diseases medicine.anatomical_structure Sjogren's Syndrome symbols Female business Spongiosis |
| Zdroj: | The American Journal of dermatopathology. 42(6) |
| ISSN: | 1533-0311 |
| Popis: | Background Primary Sjogren's syndrome (pSS) is an important cause of xerostomia, and the presence of this symptom in lupus erythematosus (LE) is usually referred to as secondary SS. Although these diseases share many clinical and laboratory aspects, the histopathological changes of minor salivary glands (MSG) have been widely evaluated to determine whether this damage is specific for each disease. Based on this query, the aim of this study was to analyze morphological findings of minor salivary glands in pSS or LE. Methods Two groups of 30 (MSG) from patients with pSS and LE were histopathologically evaluated, and the results were statistically analyzed using the two-tailed Fisher exact test. Results The morphological changes were distinct among the groups and statistically significant. In pSS, the most evident features were the focal lymphocytic ductal aggression, with the focus score ≥1 and the periductal fibroplasia, while in LE, perivascular inflammatory infiltrate, spongiosis of ductal cells not associated with the exocytosis, and hyalinization of the periductal basement membrane were detected. Conclusions These results indicated that in each disorder, MSG have their specific morphological changes, which lead to xerostomia, and the impairment of MSG in LE is probably due to a lupus sialadenitis. |
| Databáze: | OpenAIRE |
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