Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population
| Autor: | Veronica Verri, Yamila Sieza, Raquel Bengió, Myriam Attie, Irene Larripa, Yesica Soledad Bestach, Cecilia Riccheri, Moira Bolesina, Carolina Bárbara Belli |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research Adolescent Genotype Population Argentina Biology Polymorphism Single Nucleotide Interferon-gamma Young Adult Interferon γ Gene Frequency medicine Humans Aplastic anemia education Child Dinucleotide Repeats Tumor necrosis factor α Aged Antilymphocyte Serum Retrospective Studies education.field_of_study Tumor Necrosis Factor-alpha Anemia Aplastic Hematology Middle Aged medicine.disease Virology Treatment Outcome Oncology Child Preschool Immunology Cyclosporine Tumor necrosis factor alpha Drug Therapy Combination Female Immunosuppressive Agents |
| Zdroj: | Leukemialymphoma. 56(6) |
| ISSN: | 1029-2403 |
| Popis: | The impaired hematopoiesis in acquired aplastic anemia (AA) results from immune-mediated mechanisms. We characterized polymorphisms implicated in controlling type-1 cytokine production in 69 patients with AA. Our data suggest that the studied polymorphisms are not associated with susceptibility in the overall AA population. However, the presence of the higher expressing TNF - 308A allele was associated with younger age (p = 0.0297) and more profound neutropenia (p = 0.0312), and over-represented in patients with very severe AA (p = 0.0168). The higher producing IFNG 12 CA-repeat allele showed strong linkage disequilibrium with the + 874T allele, and was associated with a lower hemoglobin level (p = 0.0351). Also, the presence of at least one higher expressing variant was more frequent among patients responding to immunosuppressive treatment (p = 0.0519). Our findings suggest that the presence of higher expressing variants of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in AA patient genotypes could be related to clinical parameters, disease severity and therapy outcomes. |
| Databáze: | OpenAIRE |
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