Clear cell carcinomas of the ovary have poorer outcomes compared with serous carcinomas: Results from a single-center Taiwanese study
| Autor: | Chun-Chieh Wang, Cheng-Tao Lin, Angel Chao, Wei-Yang Chang, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Yun-Hsin Tang, Fei-Chun Ku, Jung-Erh Yang, Ting-Chang Chang, Chyong-Huey Lai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Adult medicine.medical_specialty Multivariate analysis Neoplasm Residual Adolescent Taiwan ovarian epithelial cancer Ovary Carcinoma Ovarian Epithelial Single Center 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Medicine Humans Neoplasms Glandular and Epithelial Clear-cell adenocarcinoma Stage (cooking) Aged Neoplasm Staging Retrospective Studies Gynecology Aged 80 and over Ovarian Neoplasms lcsh:R5-920 business.industry serous adenocarcinoma General Medicine Middle Aged clear cell adenocarcinoma medicine.disease Survival Analysis residual neoplasm Cystadenocarcinoma Serous Serous fluid 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cohort Multivariate Analysis Female prognosis business lcsh:Medicine (General) Clear cell Adenocarcinoma Clear Cell |
| Zdroj: | Journal of the Formosan Medical Association, Vol 117, Iss 2, Pp 117-125 (2018) |
| ISSN: | 0929-6646 |
| Popis: | Background/purpose To compare the clinical outcomes of Taiwanese patients with ovarian clear cell carcinomas (CCCs) and serous carcinomas (SCs). Methods We retrieved the clinical records of women with epithelial ovarian cancer (Stage I–IV) who received primary surgeries between 2000 and 2013. Cancer-specific survival (CSS), progression-free survival, and survival after recurrence (SAR) of CCC and SC patients were retrospectively compared. Multivariate analysis was used to identify the independent predictors of survival. Results Of 891 women diagnosed with epithelial ovarian cancer, 169 CCCs and 351 high-grade SCs were analyzed. The 5-year CSS rates of CCC patients were significantly lower than those of SC for both Stage III (22.3% vs. 47.3%, p = 0.001) and Stage IV (0% vs. 24.4%, p = 0.001) disease. In the absence of gross residual malignancies, the 5-year CSS rate was better for CCC (82.3%) than SC (75.2%, p = 0.010). The 5-year SAR rate was significantly lower for CCC than SC (14.3% vs. 24.4%, p = 0.002). Old age and residual malignancies were independent prognostic factors for CSS in the entire cohort of CCC patients. In the subgroup of Stage I CCC, positive cytology was identified as the only adverse prognostic factor for CSS. Conclusion The clinical outcomes of CCC are generally poorer than SC. Complete cytoreduction to no gross residual disease should be ideally achieved in CCC patients. A greater understanding of the molecular pathogenesis of CCC may lead to tailored therapies, ultimately optimizing outcomes. |
| Databáze: | OpenAIRE |
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