2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin toxicity in yellow perch(Perca flavescens)
| Autor: | Jan M. Spitsbergen, Richard E. Peterson, James M. Kleeman |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Gills
endocrine system medicine.medical_specialty Polychlorinated Dibenzodioxins Necrosis medicine.medical_treatment Intraperitoneal injection Thymus Gland Dioxins Kidney Toxicology Perciformes Internal medicine Edema medicine Animals heterocyclic compounds Skin Perch Dose-Response Relationship Drug biology Chemistry Myocardium Body Weight Anatomy Hyperplasia biology.organism_classification medicine.disease Pollution stomatognathic diseases Dose–response relationship Endocrinology Liver Organ Specificity Perches Toxicity medicine.symptom Digestive System Spleen |
| Zdroj: | Journal of Toxicology and Environmental Health. 23:359-383 |
| ISSN: | 0098-4108 |
| DOI: | 10.1080/15287398809531120 |
| Popis: | Growth, mortality and morphologic lesions in juvenile, hatchery-reared yellow perch, Perca flavescens, were studied after treatment with graded single doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1-125 micrograms/kg, intraperitoneally). TCDD doses of 25 and 125 micrograms/kg caused 95% mortality by 28 d after treatment, without decreasing body weight. A TCDD dose of 5 micrograms/kg resulted in progressive loss of body weight with cumulative mortality of 80% by 80 d posttreatment. Periodic handling stress did not affect the time course of mortality or cumulative percent lethality in TCDD-treated perch. Fin necrosis, petechial cutaneous hemorrhage, and ascites occurred in perch treated with 5 micrograms/kg or more of TCDD. Thymic atrophy, decreased hematopoiesis in the head kidney, fibrinous pericarditis, focal myocardial necrosis, submucosal gastric edema, and hyperplasia of the epithelium of gill filaments and lamellae occurred in perch dosed with 25 or 125 micrograms/kg. Dose-related splenic lymphoid depletion occurred in perch receiving 5 micrograms/kg or more TCDD, and hepatocyte lipidosis occurred in groups treated with doses of 1 microgram/kg or more TCDD. Thus yellow perch are as responsive to the acute toxic effects of TCDD as some of the more sensitive mammalian species, and neither loss of body weight nor histologic lesions in TCDD-treated perch are sufficient to explain mortality. |
| Databáze: | OpenAIRE |
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