Behavioral investigation of mice with experimental autoimmune encephalomyelitis
| Autor: | Antônio Lúcio Teixeira, Helton José Reis, David Henrique Rodrigues, Larissa Fonseca da Cunha Sousa, Márcia Carvalho Vilela, Aline Silva de Miranda, Norinne Lacerda-Queiroz |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Elevated plus maze
memória Encephalomyelitis Autoimmune Experimental Neurological disability experimental autoimune encephalomyelitis Disease Anxiety multiple sclerosis encefalomielite autoimune experimental lcsh:RC321-571 memory Mice Memory medicine esclerose múltipla Avoidance Learning Animals In patient Maze Learning lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Behavior Animal behavior Multiple sclerosis Experimental autoimmune encephalomyelitis Motor impairment anxiety medicine.disease ansiedade Mice Inbred C57BL Disease Models Animal Neurology compor-tamento Female Neurology (clinical) medicine.symptom Psychology Neuroscience |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 69, Iss 6, Pp 938-942 (2011) Arquivos de Neuro-Psiquiatria v.69 n.6 2011 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| ISSN: | 1678-4227 |
| Popis: | Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG35-55 model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG35-55 are probably subtle or absent. |
| Databáze: | OpenAIRE |
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