Effect of a gonadotropin inhibiting substance on the ovarian histology in mice
| Autor: | Allen H. Gates, Adrian Dronkert, Minoru Ota |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
Male Ovulation endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Stimulation Urine Biology Chorionic Gonadotropin Mice Follicle Endocrinology Internal medicine medicine Animals Humans Child media_common Ovary Ovarian histology medicine.disease medicine.anatomical_structure Child Preschool Depression Chemical Atresia Gonadotropins Pituitary Female Gonadotropin Corpus luteum |
| Zdroj: | Metabolism. 17:181-188 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(68)90146-7 |
| Popis: | The effect of a gonadotropin inhibiting substance, which was prepared from the precipitate of acidified urine of adult males by extraction with a borate buffer solution, on the ovarian structure and the ovulation in immature mice given HCG was studied. No ovulation occurred in the mice injected HCG with the inhibitor. Atretic and enlarged ovarian follicles with proliferated granulosa cells and developed antra were formed 18 hours after the injection in these animals. Later the enlarged follicle which failed to rupture without the stimulation of LH reached a stage of atresia or a corpus luteum of atresia at the center of which the ovum was present. These findings confirmed that the inhibiting substance suppressed mainly the action of LH and that its action was not a delay of ovulation but its suppression. |
| Databáze: | OpenAIRE |
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