An overview on various types of gastroretentive drug delivery system
| Autor: | Pragya Baghel, Kamesh Yadu, Tripti Naurange, Sahu Manisha, Sanjib Bahadur |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Active ingredient UDC 615.1 medicine.medical_specialty gastro retentive drug delivery system (grdss) Gastric emptying business.industry media_common.quotation_subject floating drug delivery system biomucoadhesive system gastric emptying gastro retentive drug delivery system (GRDSs) Controlled release Dosage form Bioavailability RS1-441 Pharmacy and materia medica Drug delivery Distribution (pharmacology) Medicine General Pharmacology Toxicology and Pharmaceutics business Intensive care medicine media_common |
| Zdroj: | ScienceRise: Pharmaceutical Science, Iss 6 (28), Pp 4-13 (2020) ScienceRise: Pharmaceutical Science; № 6 (28) (2020); 4-13 |
| ISSN: | 2519-4852 2519-4844 |
| Popis: | Gastro retentive drug delivery system is one of the approaches to achieve controlled drug delivery. The gastro retentive drug delivery system is a way to prolong residence time of active pharmaceutical ingredient in gastrointestinal tract. It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Controlled drug delivery creates a window of absorption that release drug for a longer duration of time before reaching absorption site. Gastro retentive drug delivery systems have gained wide variation of oral drug distribution in the area of late. It includes all the approaches that keep the dosage form in the stomach for a longer duration of time. This also enables sustained release of active pharmaceutical ingredient which in turn overcomes many limitations of conventional drug delivery systems. It has begun tremendous advances in the field of gastro-retention to meet controlled release of drugs. Aim of research.The main aim of this survey to prolong the gastric retention dosage form in the stomach and improve the medication concentration in the stomach. Material and Method.To prepare this manuscript, various keywords were searched in different search engines such as Google, Yahoo, Bing etc. The available information in public domain was collected and classified according to delivery system. This review paper aim to provide complete information about different delivery systems related to Gastro retentive drug delivery systems (GRDDS). It is also applied for targeting drug in upper gastrointestinal tract for generating local and systemic effect. Result.After going through various literatures, it can be said that the GRDDS can improve local bioavailability and therapeutic efficacy and dosing frequency possible reduction in dose size. This paper is focused on various physiological contemplation and obtainable formulation approaches for development of gastro retentive drug delivery system. Conclusions.This article discusses various types of GRDDS and their approaches. The gastric retentive drug delivery systems improve drug absorption. Prolonged gastric retention time of therapeutic mutations provide several benefits such as improving absorption, bioavailability and enhance the therapeutic action of drug |
| Databáze: | OpenAIRE |
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