Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse
| Autor: | Hongbin Cao, Richard C.K. Jordan, Veronica G. Beaudry, Laura D. Attardi, Christina S. Kong, Catherine M. Nguyen, Quynh-Thu Le, Shirley Kwok |
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| Rok vydání: | 2013 |
| Předmět: |
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Pathology medicine.disease_cause Cell Transformation 80 and over 2.1 Biological and endogenous factors Genes Tumor Suppressor Aetiology Cancer Aged 80 and over Mouth neoplasm Tissue microarray Middle Aged Cadherins Prognosis Immunohistochemistry Survival Rate Cell Transformation Neoplastic Local Mouth Neoplasms Female Oral Surgery Tumor Suppressor Adult medicine.medical_specialty Article Pathology and Forensic Medicine Rare Diseases medicine Genetics Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Dental/Oral and Craniofacial Disease Survival rate Aged Oral Dysplasia Neoplastic Chi-Square Distribution business.industry Carcinoma in situ Tumor Suppressor Proteins Membrane Proteins medicine.disease stomatognathic diseases Neoplasm Recurrence Genes Dentistry Cancer research Papilloma Surgery Neoplasm Recurrence Local Tumor Suppressor Protein p53 Carcinogenesis business Transcription Factors |
| Zdroj: | Oral surgery, oral medicine, oral pathology and oral radiology, vol 115, iss 1 |
| Popis: | Background PERP is a p53/p63-regulated gene encoding a desmosomal protein that plays a critical role in cell-cell adhesion and tumor suppression. Study Design We evaluated PERP expression in different grades of oral dysplasia (34 cases) and at different stages of invasive squamous cell carcinoma (SCC), and correlated the latter with clinical outcome. A tissue microarray consisting of nondysplastic mucosa, carcinoma in situ, SCC, and nodal metastases from 33 patients with human papilloma virus–negative SCC was stained for PERP and E-cadherin. Results Complete loss of PERP expression was associated with worse local control in patients with SCC. The 5-year local control rate was 91% for patients with partial PERP loss versus 31% for those with complete loss ( P = .01). Conclusions This is the first study to show that loss of PERP expression correlates with the transition to SCC and with increased local relapse in patients with oral cavity SCC. |
| Databáze: | OpenAIRE |
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