Aerobic fitness is inversely associated with neurohemodynamic transduction and blood pressure variability in older adults
| Autor: | Derek S. Kimmerly, Jennifer L. Petterson, Myles W. O’Brien, Carley D. O’Neill, Shilpa Dogra, Diane Ramsay, Said Mekary |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Aging medicine.medical_specialty Mean arterial pressure Sympathetic Nervous System business.industry Hemodynamics Blood Pressure Cardiorespiratory fitness Microneurography Cardiovascular System Blood pressure Heart Rate Ageing Internal medicine Circulatory system Cardiology Humans Medicine Aerobic exercise Original Article Geriatrics and Gerontology Muscle Skeletal business Aged |
| Zdroj: | GeroScience |
| ISSN: | 2509-2723 2509-2715 |
| DOI: | 10.1007/s11357-021-00389-z |
| Popis: | Higher aerobic fitness is independently associated with better cardiovascular health in older adults. The transduction of muscle sympathetic nerve activity (MSNA) into mean arterial pressure (MAP) responses provides important insight regarding beat-by-beat neural circulatory control. Aerobic fitness is negatively associated with peak MAP responses to spontaneous MSNA in young males. Whether this relationship exists in older adults is known. We tested the hypothesis that aerobic fitness was inversely related to sympathetic neurohemodynamic transduction and blood pressure variability (BPV) in older adults. Relative peak oxygen consumption (V̇O(2)peak, indirect calorimetry) was assessed in 22 older adults (13 males, 65 ± 5 years, 36.3 ± 11.5 ml/kg/min). Peroneal MSNA (microneurography) and arterial pressure (finger photoplethysmography) were recorded during ≥ 10-min of rest. BPV was assessed using the average real variability index. MAP was tracked for 12 cardiac cycles following heartbeats associated with MSNA bursts (i.e., peak ΔMAP). Peak ΔMAP responses (0.9 ± 0.6 mmHg) were negatively associated (all, P |
| Databáze: | OpenAIRE |
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