Multicomponent Approach to Bioactive Peptide-Ecdysteroid Conjugates: Creating Diversity at C6 by Means of the Ugi Reaction
| Autor: | Elena Mattiuzzo, Giampietro Viola, Alessandra Silvani, Giordano Lesma, Roberta Bortolozzi, Andrea Luraghi, Giulia Rainoldi |
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| Přispěvatelé: | Lesma, G, Luraghi, A, Rainoldi, G, Mattiuzzo, E, Bortolozzi, R, Viola, G, Silvani, A |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Ecdysteroid
multicomponent reaction multicomponent reactions 010405 organic chemistry steroid Organic Chemistry peptide-steroid conjugates 01 natural sciences Catalysis multidrug resistance steroids Ugi reaction 0104 chemical sciences Catalysi 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Bioactive peptide chemistry Organic chemistry Reactivity (chemistry) peptide-steroid conjugate Conjugate |
| Popis: | An efficient multicomponent protocol has been developed to access two different kinds of peptide–ecdysteroid conjugates. The approach exploits the reactivity of the 6-keto-7-ene group of 20-OH-ecdysone, allowing the unprecedented preparation of 6-amino and 6-isocyanide derivatives. The ecdysteroid derivatives were further employed in the Ugi reaction, together with formaldehyde and various structurally diverse carboxylic acids, isocyanides and amines, to afford a small family of potential multidrug-resistance modulators. |
| Databáze: | OpenAIRE |
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