Opposite changes in carotid versus aortic stiffness during healthy human pregnancy
| Autor: | Csilla Besenyei, Márk Kollai, Zsuzsanna Lénárd, Beatrix Mersich, Péter Studinger, János Rigó |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Carotid Artery Common Pulsatile flow Diastole Distension Pregnancy medicine.artery Internal medicine medicine Humans Longitudinal Studies cardiovascular diseases Pulse Pulse wave velocity Aorta Ultrasonography Analysis of Variance business.industry Postpartum Period General Medicine medicine.disease Vasodilation cardiovascular system Cardiology Gestation Female Vascular Resistance Aortic stiffness Pregnancy Trimesters business Blood Flow Velocity |
| Zdroj: | Clinical Science. 109:103-107 |
| ISSN: | 1470-8736 0143-5221 |
| DOI: | 10.1042/cs20040352 |
| Popis: | Systemic arterial compliance has been known to increase during healthy pregnancy, whereas, recently, the carotid artery has been reported to stiffen. To clarify this controversy, we simultaneously measured aortic PWV (pulse wave velocity) and carotid artery elastic parameters in a cohort of pregnant women. Twelve normotensive pregnant women were studied longitudinally during the three trimesters of pregnancy (T 1 , T 2 and T 3 respectively) and 12 weeks PP (post-partum). Carotid artery diastolic diameter and pulsatile distension was measured by an echo-wall tracking method and carotid pulse pressure by applanation tonometry. Carotid strain, compliance, distensibility coefficient, stiffness index β, E inc (incremental elastic modulus) and augmentation index were calculated. Aortic PWV was determined to estimate aortic distensibility. All carotid artery elastic parameters indicated significant stiffening from T 1 to T 3 (1.8±0.2 versus 2.9±0.3 mmHg for E inc ), which was reversed after delivery (2.3 ± 0.2 mmHg). Aortic PWV decreased during pregnancy (6.2 ± 0.2 versus 5.4 ± 0.2 m/s) and increased in the PP period (6.7 ± 0.2 m/s). No correlation was found between changes in carotid artery elastic parameters and changes in aortic PWV either from T 1 to T 3 or from T 3 to PP. The carotid artery exhibits regionally specific stiffening during pregnancy, which appears to represent a qualitatively different change in arterial elastic behaviour. |
| Databáze: | OpenAIRE |
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