Secretory component of epithelial cells is a surface receptor for polymeric immunoglobulins
| Autor: | S. S. Crago, R. Kulhavy, Jiri Mestecky, S J Prince |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Immunoglobulin A
Secretory component Receptors Drug Immunology Immunoglobulins Biology Epithelium HT29 Cells Humans Immunology and Allergy Trypsin Intestinal Mucosa Immunoglobulin Fragments Cells Cultured Cell Membrane Articles Molecular biology Secretory Component Immunoglobulin M Colonic Neoplasms biology.protein Immunoglobulin superfamily Antibody Immunoglobulin binding |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.147.6.1832 |
| Popis: | Epithelial cells of human fetal intestines and of a colonic carcinoma cell line (HT-29) exhibited intracellular and surface binding of polymeric immunoglobulins of IgA and IgM classes; monomeric IgA and IgG did not bind to these cells. Secretory component was identified as the receptor involved in the immunoglobulin binding. This conclusion was confirmed by the following experiments: trypsin abrogated the surface binding of polymeric immunoglobulin, reappearance of surface secretory component (SC) restored immunoglobulin binding; the appearance of SC in developing fetal tissues coincided with their potential to bind polymeric immunoglobulin; anti-SC reagents inhibited the binding of immunoglobulins to epithelial cells; and SC-containing secretory IgA did not bind to the surface of HT-29 cells. |
| Databáze: | OpenAIRE |
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