Vaccine Protection against a Heterologous, Non-Syncytium-Inducing, Primary Human Immunodeficiency Virus
| Autor: | Kamalpreet Arora, L. Jean Patterson, Marjorie Robert-Guroff, Harvinder Kaur, Phillip D. Markham, Michel Leno, Faruk Sinangil, Ersell Richardson, Philip M. McKenna, Lalita C. Murty, Anthony J. Conley, Lucretia Carter, Kristine Aldrich, Susan Zolla-Pazner |
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| Rok vydání: | 1998 |
| Předmět: |
Virus Cultivation
Pan troglodytes viruses Molecular Sequence Data Immunology Immunization Secondary Human immunodeficiency virus (HIV) Viral Pathogenesis and Immunity Heterologous HIV Infections HIV Antibodies HIV Envelope Protein gp120 Biology medicine.disease_cause Microbiology Adenoviridae HIV Envelope Protein gp160 Neutralization Tests Virology medicine Animals Humans Amino Acid Sequence Neutralizing antibody DNA Primers AIDS Vaccines Syncytium virus diseases Peptide Fragments Insect Science Humoral immunity HIV-1 biology.protein RNA Viral |
| Zdroj: | Journal of Virology. 72:10275-10280 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.72.12.10275-10280.1998 |
| Popis: | Vaccine-induced protection of chimpanzees against laboratory-adapted and syncytium-inducing, multiply passaged primary human immunodeficiency virus type 1 (HIV-1) isolates, but not against non-syncytium-inducing, minimally passaged ones, has been demonstrated. Following challenge with such an isolate, HIV-1 5016 , we obtained complete protection in one of three chimpanzees previously protected against low- and high-dose HIV-1 SF2 exposures after immunization with an adenovirus-HIV-1 MN gp160 priming–HIV-1 SF2 gp120 boosting regimen. At challenge, the protected chimpanzee exhibited broad humoral immunity, including neutralizing antibody activity. These results demonstrate the potential of this combination vaccine strategy and suggest that vaccine protection against an HIV isolate relevant to infection of people is feasible. |
| Databáze: | OpenAIRE |
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