An association between right ventricular dysfunction and sudden cardiac death
| Autor: | Sandeep G. Nair, Eric C. Stecker, Sumeet S. Chugh, Kyndaron Reinier, Jonathan Jui, Takafumi Nagaura, Audrey Uy-Evanado, Takahiro Shiota, Gregory A. Nichols, Summit Pandat |
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| Rok vydání: | 2020 |
| Předmět: |
Male
congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Multivariate analysis Heart Ventricles Ventricular Dysfunction Right 030204 cardiovascular system & hematology Risk Assessment Sudden death Article Sudden cardiac death Coronary artery disease Electrocardiography Oregon 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Risk Factors hemic and lymphatic diseases Physiology (medical) Internal medicine Humans Medicine Prospective Studies cardiovascular diseases 030212 general & internal medicine Aged Ejection fraction business.industry Odds ratio medicine.disease Confidence interval Survival Rate Death Sudden Cardiac Echocardiography Ventricular Function Right Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Heart Rhythm |
| ISSN: | 1547-5271 |
| Popis: | The effectiveness of severely reduced left ventricular ejection fraction (LVEF35%) as a predictor of sudden cardiac death (SCD) has diminished, and improvements in risk stratification await discovery of novel markers. Right ventricular (RV) abnormalities can be observed in conditions such as chronic obstructive pulmonary disease and sleep apnea, which have been linked to SCD.The purpose of this study was to evaluate whether RV abnormalities were associated with SCD after accounting for LVEF and other patient characteristics.In a large, prospective ongoing community-based study of SCD in the Portland, Oregon, metropolitan area, SCD cases (age ≥18 years; 2002-2014) were compared to controls with coronary artery disease but no SCD. Using a novel archive of digital echocardiograms, a standardized approach was used to evaluate RV basal diameter, RV end-diastolic area, and right ventricular fractional area change (RVFAC).A total of 350 subjects were studied, including 81 SCD cases (age 68.7 ± 13.6 years; 73% male) and 269 controls (age 66.5 ± 10.2 years; 69% male). In multivariate analysis, RVFAC was significantly associated with SCD (odds ratio 1.14 for each 5% decrease; 95% confidence interval 1.03-1.25; P = .01). When modeled with LVEF ≤35%, RVFAC ≤35% was significantly associated with increased risk of SCD. Individuals with both left ventricular and RV dysfunction had a 3× higher odds of SCD than those with neither (odds ratio 3.19; 95% confidence interval 1.33-7.68; P = .01).RV dysfunction was associated with a significantly increased risk of SCD independent of LVEF and, when combined with LVEF, had additive effects on SCD risk. |
| Databáze: | OpenAIRE |
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