In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts
| Autor: | Hasnain Jan, Shah Faisal, Muhammad Akbar, Sumaira Shah, muhammad Imran, Muhammad Naeem Khan, Sajjad Ali Shah, Suliman Syed, Faheem Jan, Muhammad Rizwan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Leishmania tropica Aché Insecticidal QH301-705.5 Trogoderma granarium Phytochemicals Ethyl acetate 01 natural sciences Extracts 03 medical and health sciences chemistry.chemical_compound Biology (General) Amastigote Leishmaniasis Chloroform biology Traditional medicine Sitophilus biology.organism_classification language.human_language 030104 developmental biology chemistry Ajuga bracteosa language Original Article Artemia salina General Agricultural and Biological Sciences 010606 plant biology & botany Cytotoxic potential |
| Zdroj: | Saudi Journal of Biological Sciences, Vol 28, Iss 5, Pp 3031-3036 (2021) Saudi Journal of Biological Sciences |
| Popis: | This research study is mainly focused to evaluate the anti-parasitic, insecticidal, cytotoxic and anti-alzheimer potential of various leaf extracts of Ajuga bracteosa Wallich ex Bentham. 04 different extracts were prepared using solvent of different polarity to determine the best candidate for potent bioactivity i.e. n-hexane (NH), Ethyl acetate (EA), Ethanol (EL) and Chloroform (CH). Concentrations of each extracts were made specified for all activities. All extracts were exploited for broad range of biomedical applications including leishmaniasis, in vitro anti-Alzheimer, insecticidal and cytotoxic studies. Our results showed that A. bracteosa n-hexane extract was highly active against Leishmania Tropica with significant inhibition of 58 ± 1.61 for promastigote and 63 ± 2.29 for amastigote at 1000 μg/mL. Furthermore, promising anti-alzheimer activity acetylcholinesterase (AChE) 46 ± 0.83 and butrylcholineterase (BChE) 49 ± 1.17 was noted for n-hexane. The insecticidal potential of these extracts were test against five different insects (Rhyzopertha dominica, Trogoderma granarium, Tribolium castaneum, Sitophilus oryze, and Callosobruchus analis). The higest mortality rate of insecticidal activity was recorded by n-hexane followed by Ethyl acetate whereas ethanol extract was found to be less effective against all the test species. Significant cytotoxic potential of each plant sample against Artemia salina thus aware us for further detailed research to find out novel drugs. Based on our results we believe that Ajuga bracteosa could be used to develop as a potential botanical insecticide against different insect and pests, such as aphids as well as an excellent source for the compound isolation as anti-tumor agent. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|