Thiamine deficiency in a patient with recurrent renal cell carcinoma who developed weight loss with normal appetite and loss of energy soon after nivolumab treatment
| Autor: | Nozomu Uchida, Hideki Onishi, Suguru Shirotake, Mayumi Ishida, Maki Todo, Masafumi Oyama, Takashi Okabe |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Malabsorption Ataxia Appetite Neurological examination Gastroenterology 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Recurrence Weight loss Internal medicine Weight Loss medicine Humans 030212 general & internal medicine Adverse effect Carcinoma Renal Cell Fatigue General Nursing Aged medicine.diagnostic_test business.industry Thiamine Deficiency Cancer General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Nivolumab 030220 oncology & carcinogenesis Thiamine medicine.symptom business |
| Zdroj: | Palliative and Supportive Care. 18:241-243 |
| ISSN: | 1478-9523 1478-9515 |
| DOI: | 10.1017/s1478951519000658 |
| Popis: | BackgroundNivolumab has become an effective treatment option for cancer in various sites; however, this drug may cause immune-related adverse effects due to its mechanism of action. Furthermore, little has been reported on thiamine deficiency (TD) in patients receiving nivolumab treatment.MethodFrom a series of cancer patients, we reported a patient with recurrent renal cell carcinoma who developed TD after the start of nivolumab treatment.ResultsA 74-year-old man with recurrent renal cell carcinoma was referred to the psycho-oncology department as he had lost about 4 kg and displayed a loss of energy after four cycles of nivolumab treatment. Psychiatric interviews revealed a decrease in energy. Neurological examination did not reveal any impairment in consciousness, ataxia, or ocular symptoms. He did not develop appetite loss. The malabsorption or overconsumption of some nutrients is thought to occur due to the rapid loss of weight; thus, a reduction in vitamin B1, which has a short storage period in the body and is often deficient in cancer patients, was suspected. The diagnosis of TD was supported by the patient's abnormally low serum thiamine level.Significance of resultsIn patients treated with nivolumab, it is necessary to pay careful attention to TD when proceeding with the treatment. It is hoped that future research may reveal the link between nivolumab administration and TD. |
| Databáze: | OpenAIRE |
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