| Autor: |
Changjun Zhang, Yujia Zhang, Yangjing Lv, Jianan Guo, Bianbian Gao, Yi Lu, Anjie Zang, Xi Zhu, Tao Zhou, Yuanyuan Xie |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of enzyme inhibition and medicinal chemistry. 38(1) |
| ISSN: |
1475-6374 |
| Popis: |
Based on the multitarget-directed ligands (MTDLs) strategy, a series of chromone-hydroxypyridinone hybrids were designed, synthesised, and evaluated as potential multimodal anti-AD ligands. Prospective iron-chelating effects and favourable monoamine oxidase B (MAO-B) inhibitory activities were observed for most of the compounds. Pharmacological assays led to the identification of compound |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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