Contemporary Issues in Pregnancy (and Offspring) in the Current HIV Era
| Autor: | Nancy L Hagood, Stephanie E Kirk, Allison Ross Eckard |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Anti-HIV Agents Offspring Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Pregnancy Virology medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Child Subclinical infection business.industry Infant Newborn Infant medicine.disease Antiretroviral therapy Infectious Disease Transmission Vertical Mitochondrial toxicity 030104 developmental biology Infectious Diseases Premature birth Etiology Female business |
| Zdroj: | Curr HIV/AIDS Rep |
| ISSN: | 1548-3576 1548-3568 |
| DOI: | 10.1007/s11904-019-00465-2 |
| Popis: | PURPOSE OF REVIEW: Although antiretroviral therapy (ART) has dramatically reduced mother to child transmission of HIV, data continue to mount that infants exposed to HIV in utero but are not infected (HEU) have serious negative health consequences compared to unexposed infants. This review evaluates recent literature on contemporary issues related to complications seen in pregnant women with HIV and their offspring. RECENT FINDINGS: Current studies show that HEU infants are at a high risk of adverse outcomes, including premature birth, poor growth, neurodevelopmental impairment, immune dysfunction, infectious morbidity, and death. Etiologies for the observed clinical events and subclinical alterations are complex and multifactorial, and the long-term consequences of many findings are yet unknown. SUMMARY: HEU infants have an unacceptable rate of morbidity and mortality from perinatal HIV and ART exposure, even in the modern ART era. Continual monitoring and reporting is imperative to protect this vulnerable population in our everchanging landscape of HIV treatment and prevention. |
| Databáze: | OpenAIRE |
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