Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents
| Autor: | Abdur Rahman, Abdullah Al-Taiar, Jehad Abubaker, Reem Al-Sabah, Nada Alam-Eldin, Mohamed Abu-Farha, Fahd Al-Mulla, Lemia Shaban, Maha M. Hammad |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Adolescent Oxidized low density lipoprotein lcsh:Medicine 030209 endocrinology & metabolism Overweight Article Correlation 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal medicine Prevalence Humans Medicine Triglyceride metabolism Obesity Child lcsh:Science Dyslipidaemias Multidisciplinary biology business.industry lcsh:R C-reactive protein medicine.disease Lipoproteins LDL Angiopoietin-like Proteins C-Reactive Protein Cross-Sectional Studies 030104 developmental biology Endocrinology Kuwait Cardiovascular Diseases biology.protein Female lcsh:Q medicine.symptom business Biomarkers Lipoprotein |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-63076-7 |
| Popis: | Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11–14 years) were randomly selected from middle schools in Kuwait. Obesity was classified by the BMI-for-age based on the WHO growth charts. Plasma ANGPTL5, HsCRP, and Ox-LDL were measured using ELISA. The prevalence of overweight and obesity was 20.65% and 33.18%, respectively. Mean (SD) plasma ANGPTL5 levels were significantly higher in obese, compared with overweight and normal-weight adolescents (23.05 (8.79) vs 18.39 (7.08) ng/mL, and 18.26 (6.95) ng/ml, respectively). ANGPTL5 was positively associated with both HsCRP (ρ=0.27, p |
| Databáze: | OpenAIRE |
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