Polymerase chain reaction (PCR) in ocular and ganglionar toxoplasmosis and the effect of therapeutics for prevention of ocular involvement in South American setting
| Autor: | Juan David Zuluaga, Jorge Enrique Gómez Marín, Alejandra de-la-Torre, Jessica Triviño, Eunice Julied Pechené Campo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Sulfamethoxazole Epidemiology Lymphadenopathy Procedures Polymerase Chain Reaction Trimethoprim Vitreous body detachment ocular 0302 clinical medicine Eye disease Immunoglobulin m Chill Immunoglobulin g Optic disk Child Infectious disease Primary prevention Sequence analysis Polymerase chain reaction Retrospective study Ganglion cyst Medical history Toxoplasma Human Diarrhea medicine.medical_specialty Vitritis Disease treatment Ganglion cysts Vomiting Veterinary (miscellaneous) Prednisolone Symptom Retinitis Major clinical study Colombia Article Treatment duration 03 medical and health sciences Blurred vision Epiretinal membrane Genetics Humans Retrospective Studies Aged Ganglion Cysts Consultation Chorioretinitis Very elderly Follow up medicine.disease Toxoplasmosis Cotrimoxazole Ophthalmoscopy Retrospective studies 030104 developmental biology Retina macula cystoid edema Insect Science Asymptomatic disease Parasitology Comparative study American 0301 basic medicine Enzyme linked immunosorbent assay Ocular toxoplasmosis Tropical medicine Best corrected visual acuity Middle aged Developing world Clindamycin Middle Aged Pyrimethamine plus sulfadoxine Ganglionar toxoplasmosis Infectious Diseases Pyrimethamine Toxoplasmic lymphadenitis Female medicine.symptom Cervical lymphadenopathy Adult Retina detachment Visual acuity Adolescent Fever 030231 tropical medicine Asymptomatic Blood analysis Uveitis Physical examination Lymphadenitis Sulfadoxine medicine Personal experience Toxoplasmosis Ocular business.industry Iridotomy Dermatology Isolation and purification business Controlled study |
| Zdroj: | Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario |
| Popis: | Introduction: Cases of toxoplasmosis present in South America tend to be more severe than that found in other continents. Here, we present our clinical experience of ocular and ganglionar toxoplasmosis in the use of PCR, and of the treatment to prevent ocular involvement. Methodology: Retrospective analysis of clinical charts of patients with ocular and lymphadenitic toxoplasmosis at the parasitology and tropical medicine consultation in the “Universidad del Quindio” in Colombia. In total, 91 records of cases with ocular toxoplasmosis and 17 with lymphadenitis that underwent PCR analysis for B1 repeated sequence in blood, were compared to the results of 104 people with chronic asymptomatic toxoplasmosis. In addition, 41 clinical records were included from patients with confirmed toxoplasmic lymphadenitis: 10 untreated, 6 that begun treatment after four months of symptoms, and 25 that were treated during the first four months of symptoms and had a follow-up during at least one year. Results: Patients with ocular toxoplasmosis or lymphadenitis had a higher probability of PCR positivity in peripheral blood than chronic asymptomatic people. There were no cases of retinochoroiditis in 25 patients with toxoplasmic lymphadenitis treated before 4 months of symptoms and followed during at least 12 months. In four out of ten untreated cases, new lesions of retinochoroiditis presented after the symptoms of lymphadenitis. Conclusions: Toxoplasmosisin South America exhibits different clinical behavior and this influences the laboratory results as well as the need for treatment in the case of lymphadenitis. Clinicians should be aware of the geographical origin of the infection in order to adopt different therapeutic and diagnostic approaches. © 2018 Elsevier B.V. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|