Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae
| Autor: | Yftah Tal-Gan, Yifang Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Peptide
Computational biology medicine.disease_cause 01 natural sciences Biochemistry Article Structure-Activity Relationship Bacterial Proteins Drug Discovery Streptococcus pneumoniae parasitic diseases medicine Structure–activity relationship Receptor Molecular Biology chemistry.chemical_classification 010405 organic chemistry Organic Chemistry fungi Membrane Proteins Quorum Sensing medicine.disease Transmembrane protein 0104 chemical sciences 010404 medicinal & biomolecular chemistry Pneumococcal infections Quorum sensing chemistry Peptides Receptor activation |
| Zdroj: | Bioorg Chem |
| ISSN: | 1090-2120 |
| Popis: | The competence stimulating peptide (CSP) plays a key role in the regulation of pneumococcal quorum sensing (QS), a communication system that is critical to the infectivity of pneumococci. CSP functions through binding and activating a transmembrane receptor, Com D. Molecules that can modulate pneumococcal QS through intercepting CSP: Com D interaction may serve as new generation of antibacterial agents to treat pneumococcal infections. In this work, we systematically modified the N-terminus of CSP1, a region that is essential to Com D activation, to identify detailed structural features of the N-terminus that are responsible for its function. Our results revealed structural features that are optimal to achieve receptor activation and structure-activity trends that improve our understanding of CSP: Com D interaction, all of which will contribute to the design of novel pneumococcal QS modulators with higher potency and improved pharmacological properties. |
| Databáze: | OpenAIRE |
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