The relationship of prenatal and infant antibiotic exposure with childhood overweight and obesity:A systematic review
| Autor: | Isolde Besseling-van der Vaart, Ruth Baron, Joanne K Ujcic-Voortman, Jacob C. Seidell, Meron Taye, Arnoud P. Verhoeff, Hania Szajewska |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pediatric Obesity
Pediatrics medicine.medical_specialty medicine.drug_class Antibiotics Medicine (miscellaneous) microbiome 030209 endocrinology & metabolism Overweight antibiotics Early life chronic diseases 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Pregnancy Risk Factors medicine Humans 030212 general & internal medicine Child Netherlands business.industry Confounding Infant Odds ratio medicine.disease overweight and obesity Obesity Anti-Bacterial Agents Systematic review Prenatal Exposure Delayed Effects Relative risk Female Observational study medicine.symptom business |
| Zdroj: | Baron, R, Taye, M, Besseling-Van Der Vaart, I, Ujčič-Voortman, J, Szajewska, H, Seidell, J C & Verhoeff, A 2020, ' The relationship of prenatal and infant antibiotic exposure with childhood overweight and obesity : A systematic review ', Journal of Developmental Origins of Health and Disease, vol. 11, no. 4, pp. 335-349 . https://doi.org/10.1017/S2040174419000722 |
| DOI: | 10.1017/S2040174419000722 |
| Popis: | This study aimed to assess the evidence regarding the relationship between early-life antibiotic exposure and childhood overweight/obesity by reviewing observational studies on prenatal antibiotic exposure and systematic reviews on infant antibiotic exposure. A search in Pubmed, Embase and Google Scholar covering the period 1st January till 1st December 2018 led to the identification of five studies on prenatal antibiotic exposure and four systematic reviews on infant antibiotic exposure. Positive trends between prenatal antibiotic exposure and overweight/obesity were reported in all studies; two studies reported a significant overall relationship and the other three reported significant relationships under certain conditions. Effect sizes ranged from odds ratio (OR): 1.04 (0.62–1.74) to relative risk (RR): 1.77 (1.25–2.51). Regarding infant antibiotics, one review concluded there was substantial evidence that infant antibiotic exposure increased the risk of childhood overweight/obesity [pooled effect sizes: RR: 1.21 (1.09–1.33) for overweight and RR: 1.18 (1.12–1.25) for obesity]. Two reviews concluded there was some evidence for a relationship [pooled effect sizes: OR: 1.05 (1.00–1.11) and OR: 1.11 (1.02–1.20)]. The fourth review concluded the studies were too heterogeneous for meta-analyses and the evidence regarding the relationship between infant antibiotic exposure and childhood overweight/obesity was inconclusive. More well-designed studies are needed that include data on intra-partum antibiotics and address important potential confounders (including maternal and childhood infections). This review points to some evidence of a relationship between early-life antibiotic exposure and childhood overweight/obesity; this is especially evident in certain children (i.e. exposed to multiple and broad-spectrum antibiotics, earlier postnatal exposure and male gender) and merits further research. |
| Databáze: | OpenAIRE |
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